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Titolo:
Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease - Pathophysiological implications
Autore:
Monaco, C; Crea, F; Niccoli, G; Summaria, F; Cianflone, D; Bordone, R; Bellomo, G; Maseri, A;
Indirizzi:
Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy Univ Cattolica Sacro Cuore Rome Italy I-00168 rdiol, I-00168 Rome, Italy Univ Turin, Dipartimento Sci Med, Novara, Italy Univ Turin Novara ItalyUniv Turin, Dipartimento Sci Med, Novara, Italy
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 17, volume: 22, anno: 2001,
pagine: 1572 - 1577
SICI:
0195-668X(200109)22:17<1572:AAOLDL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE CORONARY SYNDROMES; ENHANCED MACROPHAGE DEGRADATION; MALONDIALDEHYDE-MODIFIED LDL; ACUTE MYOCARDIAL-INFARCTION; ARTERY DISEASE; ATHEROSCLEROTIC LESIONS; CAROTID ATHEROSCLEROSIS; ENDOTHELIAL-CELLS; HEART-DISEASE; NEUTROPHIL;
Keywords:
lipoproteins; antibodies; inflammation; coronary artery disease; peripheral artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Crea, F Univ Cattolica Sacro Cuore, Ist Cardiol, Lgo A Gemelli 8, I-00168 Rome, Italy Univ Cattolica Sacro Cuore Lgo A Gemelli 8 Rome Italy I-00168 aly
Citazione:
C. Monaco et al., "Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease - Pathophysiological implications", EUR HEART J, 22(17), 2001, pp. 1572-1577

Abstract

Background Antibody antioxidized low density lipoproteins (oxLDL) might play a role both in atherogenesis and in the pathogenesis of acute coronary syndromes. Methods and Results Antibody titres to oxLDL and levels of C-reactive protein were compared in unstable angina, stable angina or peripheral artery disease. Antibody titres to LDL oxidated by CuSO4 for 2. 4 and 18 h (Cu-oxLDL-Ab(2-4-18)) or by peroxidase (HRP-oxLDL-Ab) were assessed by ELISA. Cu-oxLDL-Ab(2-4-18) were consistently higher in peripheral artery disease than inunstable angina (P < 0.001. P < 0.001, P = 0.01. respectively) or in stable angina (P < 0.001. P = 0.01. P = ns) but similar in unstable and stable angina. Accordingly, HRP-oxLDL-Ab were higher in peripheral artery disease than in unstable angina (P < 0.001) or stable angina (P = 0.04) but similar in unstable and stable angina. The number or arterial stenoses was higher in peripheral artery disease than unstable and stable angina (P < 0.01). Cu-oxLDL-Ab and HRP-oxLDL-Ab correlated with the severity of atherosclerosis (P < 0.01, R = 0.4: P = 0.02, R = 0.3 respectively). Conversely, C-reactive protein levels were higher in unstable than in stable angina (P < 0.001) orin peripheral artery disease (P < 0.03) but similar in stable angina and peripheral artery disease and did not correlate with the severity of atherosclerosis. Conclusion The autoimmune response to oxLDL is likely to play an importantrole in atherogenesis but not in precipitating acute coronary syndromes. (Eur Heart J 2001; 22: 1572-1577, doi:10.1053/euhj.2000. 2554) (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 17:51:35