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Titolo:
Xenopus FRS2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo
Autore:
Kusakabe, M; Masuyama, N; Hanafusa, H; Nishida, E;
Indirizzi:
Kyoto Univ, Grad Sch Sci, Dept Biophys, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 t Biophys, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ, Grad Sch Biostudies, Dept Cell & Dev Biol, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Dev Biol, Sakyo Ku, Kyoto 6068502, Japan
Titolo Testata:
EMBO REPORTS
fascicolo: 8, volume: 2, anno: 2001,
pagine: 727 - 735
SICI:
1469-221X(200108)2:8<727:XFIIIE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; MESODERM INDUCTION; MAP KINASE; TYROSINE-PHOSPHATASE; RECEPTOR ACTIVATION; FGF; SNT; PROTEINS; DIFFERENTIATION; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Nishida, E Kyoto Univ, Grad Sch Sci, Dept Biophys, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Sakyo Ku, Kyoto 6068502, Japan
Citazione:
M. Kusakabe et al., "Xenopus FRS2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo", EMBO REP, 2(8), 2001, pp. 727-735

Abstract

FRS2 has been identified in mammalian cells as a protein that is tyrosine phosphorylated and binds to Grb2 and Shp2 in response to fibroblast growth factor (FGF) or nerve growth factor (NGF) stimulation. But neither its existence in other vertebrate classes or invertebrates nor its function during embryonic development has been defined. Here we have identified and characterized a Xenopus homolog of FRS2 (xFRS2). xFRS2 is tyrosine phosphorylated in early embryos, and overexpression of an unphosphorylatable form of xFRS2interferes with FGF-dependent mesoderm formation. The Src family kinase Laloo, which was shown to function in FGF signaling during early Xenopus development, binds to xFRS2 and promotes tyrosine phosphorylation of xFRS2. Moreover, xFRS2 and Laloo are shown to bind to Xenopus FGF receptor 1. These results suggest that xFRS2 plays an important role in FGF signaling in cooperation with Laloo during embryonic development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:26:18