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Titolo:
An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR inthe maturation of cytosolic Fe/S proteins
Autore:
Lange, H; Lisowsky, T; Gerber, J; Muhlenhoff, U; Kispal, G; Lill, R;
Indirizzi:
Univ Marburg, Inst Zytobiol & Zytopathol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 ytopathol, D-35033 Marburg, Germany Univ Dusseldorf, Inst Bot, Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany ldorf, Inst Bot, Dusseldorf, Germany Univ Pecs, Sch Med, Inst Biochem, H-7624 Pecs, Hungary Univ Pecs Pecs Hungary H-7624 ch Med, Inst Biochem, H-7624 Pecs, Hungary
Titolo Testata:
EMBO REPORTS
fascicolo: 8, volume: 2, anno: 2001,
pagine: 715 - 720
SICI:
1469-221X(200108)2:8<715:AEFOTM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IRON-SULFUR PROTEINS; REGENERATION ALR GENE; SACCHAROMYCES-CEREVISIAE; LIVER-REGENERATION; YEAST; EXPRESSION; BIOGENESIS; PHOSPHORYLATION; AUGMENTOR; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lill, R Univ Marburg, Inst Zytobiol & Zytopathol, Robert Koch Str 5, D-35033 Marburg, Germany Univ Marburg Robert Koch Str 5 Marburg Germany D-35033g, Germany
Citazione:
H. Lange et al., "An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR inthe maturation of cytosolic Fe/S proteins", EMBO REP, 2(8), 2001, pp. 715-720

Abstract

Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Here, we identify the essential Erv1p of Saccharomyces cerevisia mitochondria as a novel component that is specifically required for the maturation of Fe/S proteins in the cytosol, but not in mitochondria. Furthermore, Erv1p was found to be important for cellular iron homeostasis. The homologous mammalian protein ALR ('augmenter of liver regeneration'), also termed hepatopoietin, can functionally replace defects in Erv1p and thus represents the mammalian orthologue of yeast Erv1p. Previously, a fragment of ALR was reported to exhibit an activity as an extracellular hepatotrophic growth factor. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane space and represent the first components of this compartment with a role in the biogenesis of cytosolic Fe/S proteins. It is likely that Erv1p/ALR operates downstream of the mitochondrial ABC transporter Atm1p/ABC7/Sta1, which also executes a specific task in this essential biochemical process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:18:09