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Titolo:
YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids
Autore:
Beck, K; Eisner, G; Trescher, D; Dalbey, RE; Brunner, J; Muller, M;
Indirizzi:
Univ Freiburg, Inst Biochem & Mol Biol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 l Biol, D-79104 Freiburg, Germany Univ Freiburg, Fak Biol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 k Biol, D-79104 Freiburg, Germany Ohio State Univ, Dept Chem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 , Dept Chem, Columbus, OH 43210 USA ETH Zurich, Inst Biochem, CH-8092 Zurich, Switzerland ETH Zurich Zurich Switzerland CH-8092 ochem, CH-8092 Zurich, Switzerland
Titolo Testata:
EMBO REPORTS
fascicolo: 8, volume: 2, anno: 2001,
pagine: 709 - 714
SICI:
1469-221X(200108)2:8<709:YAASFP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-RECOGNITION PARTICLE; INNER MEMBRANE; TARGETING PATHWAYS; TRIGGER FACTOR; INTEGRATION; SRP; INSERTION; HOMOLOG; EXPORT; OXA1P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, M Univ Hawaii Manoa, Pacific Biomed Res Ctr, 1993 E West Rd, Honolulu, HI 96822 USA Univ Hawaii Manoa 1993 E West Rd Honolulu HI USA 96822 96822 USA
Citazione:
K. Beck et al., "YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids", EMBO REP, 2(8), 2001, pp. 709-714

Abstract

Like its mitochondrial homolog Oxa1p, the inner membrane protein YidC of Escherichia coli is involved in the integration of membrane proteins. We have analyzed individual insertion steps of the polytopic E coli membrane protein MtIA targeted as ribosome-nascent chain complexes to inner membrane vesicles. YidC can accommodate at least the first two transmembrane segments of MtIA at the protein lipid interface and retain them even though the length of the nascent chain would amply allow insertion into membrane lipids. Aneven longer insertion intermediate of MtIA is described that still has thefirst transmembrane helix bound to YidC while the third contacts SecE and YidC during integration. Our findings suggest that YidC forms a contiguous integration unit with the SecYE translocon and functions as an assembly site for polytopic membrane proteins mediating the formation of helix bundles prior to their release into the membrane lipids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:21:20