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Titolo:
Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer
Autore:
Makino, N; Yamato, T; Inoue, H; Furukawa, T; Abe, T; Yokoyama, T; Yatsuoka, T; Fukushige, S; Orikasa, S; Takahashi, T; Horii, A;
Indirizzi:
Tohoku Univ, Sch Med, Dept Mol Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ, Sch Med, Dept Urol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Yamagata Univ, Sch Med, Dept Internal Med 2, Yamagata 9909585, Japan Yamagata Univ Yamagata Japan 9909585 rnal Med 2, Yamagata 9909585, Japan
Titolo Testata:
DNA SEQUENCE
fascicolo: 6, volume: 11, anno: 2001,
pagine: 547 - 553
SICI:
1042-5179(2001)11:6<547:IACOTH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-CELL CARCINOMA; ANGIOGENESIS; INHIBITOR;
Keywords:
the headcase gene; human pancreatic cancer; chromosome arm 6q;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Horii, A Tohoku Univ, Sch Med, Dept Mol Pathol, Aoba Ku, 2-1 Seiryo Machi,Sendai, Miyagi 9808575, Japan Tohoku Univ 2-1 Seiryo Machi Sendai Miyagi Japan 9808575 5, Japan
Citazione:
N. Makino et al., "Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer", DNA SEQ, 11(6), 2001, pp. 547-553

Abstract

Deletions of the long arm of chromosome 6 (6q) are one of the most common chromosomal abnormalities in multiple human malignancies. Previously, we have identified three commonly deleted regions on 6q (6q21, 6q23-q24, and 6q26) in pancreatic cancer by loss of heterozygosity studies, suggesting the presence of one or more tumor suppressor genes on this chromosome arm. Usinga combination of database search and cDNA library screening, we successfully isolated a transcript from 6q24. This mRNA encodes a protein consisting of 543 amino acids with homology to the Drosophila headcase (hdc) gene and,thus, is designated as hHDC. Northern analysis identified a ubiquitously expressed 5.6-kb transcript. Seventeen (81%) of 21 pancreatic cancer cell lines and four (80%) of five renal cell carcinoma cell lines showed low levelexpression, suggesting that the hHDC gene may play an important role in some human cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:35:15