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Titolo:
Cloning of a cDNA encoding an isoform of human protein phosphatase inhibitor 2 from vascularized breast tumor
Autore:
Wu, IM; Moses, MA;
Indirizzi:
Childrens Hosp, Surg Res Lab, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 sp, Surg Res Lab, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Sch Med, Dept Surg, Boston, MA 02115 USA
Titolo Testata:
DNA SEQUENCE
fascicolo: 6, volume: 11, anno: 2001,
pagine: 515 - 518
SICI:
1042-5179(2001)11:6<515:COACEA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-TISSUE INHIBITOR; EXPRESSION; ANGIOGENESIS; CANCER;
Keywords:
breast cancer; angiogenesis; protein phosphatases inhibitor 2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Moses, MA Childrens Hosp, Surg Res Lab, 320 Longwood Ave, Boston, MA 02115USA Childrens Hosp 320 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
I.M. Wu e M.A. Moses, "Cloning of a cDNA encoding an isoform of human protein phosphatase inhibitor 2 from vascularized breast tumor", DNA SEQ, 11(6), 2001, pp. 515-518

Abstract

Using modified differential display, a gene fragment was identified as being over-expressed in human vascularized breast carcinoma when compare to its neighboring normal tissue. The differentially expressed pattern was confirmed by quantitative RT-PCR. Full-length cDNA was then cloned by both 3 ' -end RACE and 5 ' -end RACE. Analysis of the full-length cDNA of this gene reveals that this cDNA encodes an open reading frame of 615 bp, which is highly homologous to human protein phosphatase inhibitor-2, with 92% identity at the nucleotide level, and 89% identity at amino acid level. The results of this study suggest that this novel isoform of human protein phosphatase inhibitor-2 (nPPI-2) may be involved in the angiogenic switch during breasttumor development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:55:26