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Titolo:
Comparative accuracy of cardiovascular risk prediction methods in patientswith diabetes mellitus
Autore:
Game, FL; Bartlett, WA; Bayly, GR; Jones, AF;
Indirizzi:
Nottingham City Hosp NHS Trust, Dept Endocrinol & Diabet, Nottingham NG5 1PB, England Nottingham City Hosp NHS Trust Nottingham England NG5 1PB 5 1PB, England Birmingham Heartlands & Solihull NHS Trust, Dept Clin Biochem, Birmingham,W Midlands, England Birmingham Heartlands & Solihull NHS Trust Birmingham W Midlands England Bristol Royal Infirm & Gen Hosp, Dept Chem Pathol, Bristol, Avon, England Bristol Royal Infirm & Gen Hosp Bristol Avon England stol, Avon, England
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 4, volume: 3, anno: 2001,
pagine: 279 - 286
SICI:
1462-8902(200108)3:4<279:CAOCRP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; AVERAGE CHOLESTEROL LEVELS; PRIMARY PREVENTION; EVENTS;
Keywords:
diabetes mellitus; cardiovascular risk; Framingham equation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Game, FL Nottingham City Hosp NHS Trust, Dept Endocrinol & Diabet, Hucknall Rd, Nottingham NG5 1PB, England Nottingham City Hosp NHS Trust Hucknall Rd Nottingham England NG5 1PB
Citazione:
F.L. Game et al., "Comparative accuracy of cardiovascular risk prediction methods in patientswith diabetes mellitus", DIABET OB M, 3(4), 2001, pp. 279-286

Abstract

Objective: To compare the accuracy of cardiovascular risk prediction methods based on equations derived from the Framingham Heart Study in a cohort of patients with diabetes mellitus. Research design and methods: Risk factor data was collected prospectively from 906 patients with diabetes mellitus. Absolute cardiovascular risks were calculated using the Framingham equation, and estimated with the currently available Framingham-based risk tables and charts. The sensitivity, specificity, positive and negative predictive values of the tables and charts toassess cardiovascular risk were assessed using calculation of risk from the full Framingham equation as the reference method. Results: In all, 146 subjects (16.1%) had calculated 10-year coronary heart disease (CHD) risks greater than or equal to 30%, and 585 (64.6%) had risks greater than or equal to 15%. For identification of those at 10-year CHDrisk greater than or equal to 30%, the original Sheffield tables had a sensitivity of 43% (95% confidence intervals (GI) 19.9-61.7%) and specificity of 94% (Cl 90.8-96.7%). Modifications of the Sheffield tables improve sensitivity (95% Cl 93.9-97%) but reduce specificity (90% CI 85.6-95.7%). The joint British Guidelines' charts have a moderate sensitivity (69.5% CI 51.8-81.9%) and high specificity (99.7% CI 98.9-100%). For identification of individuals at a 10-year CHD risk greater than or equal to 27%, the Framingham categorical tables had a sensitivity of 95% [CI 91.6-97.8%), but a specificity of only 83% (95% CI 79.1-85.5%),Conclusions: The joint British charts appear to have the best performance in a cohort of patients with diabetes mellitus, however, calculation of CHD/CVD (cardiovascular disease) risks with personal or laboratory computers using the full Framingham equation remains the most accurate way to assess cardiovascular risk in a primary prevention setting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:32:11