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Titolo:
Effects of chronic treatment with acarbose on glucose and lipid metabolismin obese diabetic Wistar rats
Autore:
Carrascosa, JM; Molero, JC; Fermin, Y; Martinez, C; Andres, A; Satrustegui, J;
Indirizzi:
Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa,Dept Biol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 iol Mol, E-28049 Madrid, Spain Univ Castilla La Mancha, Fac Quim, Dept Bioquim, E-13071 Ciudad Real, Spain Univ Castilla La Mancha Ciudad Real Spain E-13071 071 Ciudad Real, Spain
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 4, volume: 3, anno: 2001,
pagine: 240 - 248
SICI:
1462-8902(200108)3:4<240:EOCTWA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETICALLY-OBESE; NIDDM PATIENTS; 24-WEEK MONOTHERAPY; CLINICAL-TRIAL; BLOOD-GLUCOSE; FATTY RAT; INSULIN; PLACEBO; EFFICACY; MELLITUS;
Keywords:
acarbose; obesity; lipid metabolism; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Carrascosa, JM Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa,Dept Biol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid MadridSpain E-28049 9 Madrid, Spain
Citazione:
J.M. Carrascosa et al., "Effects of chronic treatment with acarbose on glucose and lipid metabolismin obese diabetic Wistar rats", DIABET OB M, 3(4), 2001, pp. 240-248

Abstract

Aims: The effect of chronic treatment with acarbose on fasting plasma glucose, insulin, triglyceride, cholesterol and free fatty acid (FFA) concentrations, as well as on the glucose and insulin excursions during oral glucosetolerance test (OGTT), in obese diabetic Wistar (WDF) rats was investigated. Methods: Forty-five mature male WDF rats were randomly distributed to one of the three treatment groups (no acarbose, 20 mg and 40 mg of acarbose/100g of chow, respectively). After 3.5, 7.5 and 11.5 months, animals were tested for glucose tolerance by means of an OGTT, and their respective metabolic profiles were determined. Control determinations were done in obese and age-matched lean animals before the start of the trial. Results: The WDF rats exhibit higher body weight and fasting blood glucose, insulin, triglyceride and cholesterol concentrations compared to lean animals. Moreover, they show marked glucose intolerance as indicated by the glucose and insulin excursions during OGTT. Interestingly, in both treated and untreated animals, a reversion of the hyperglycaemic state as well as an improvement of the glucose tolerance is observed. However, whereas in the group receiving no acarbose this is accounted for by dramatic increases in fasting plasma insulin concentrations and insulin secretion during OGTT (as indicated by the, Delta Insulin area), in rats treated with acarbose the reversion of the diabetic state takes place without increments in hormone concentration. In addition, rats treated with acarbose for 3.5 and 7.5 months show lower plasma triglyceride and FFA concentrations, and the same was observed for cholesterol at the highest dosage of the drug. Conclusions: Chronic treatment with acarbose of WDF rats improves the glycaemic and lipidic control as well as the glucose tolerance, with a lower demand of pancreatic insulin than in untreated rats. This data suggests that the long-term modulation of glucose and insulin excursions after meals improves the insulin sensitivity in this rat strain.

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Documento generato il 25/01/20 alle ore 19:09:56