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Titolo:
Developmental vulnerabilities to the onset and course of bipolar disorder
Autore:
Post, RM; Leverich, GS; Xing, GQ; Weiss, SRB;
Indirizzi:
NIMH, Biol Psychiat Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 , Biol Psychiat Branch, Bethesda, MD 20892 USA Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20814 Bethesda, MD 20814 USA
Titolo Testata:
DEVELOPMENT AND PSYCHOPATHOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 581 - 598
SICI:
0954-5794(200122)13:3<581:DVTTOA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; GLUCOCORTICOID-RECEPTOR FUNCTION; SUBGENUAL PREFRONTAL CORTEX; FAMILIAL MOOD DISORDERS; BIRTH-COHORT CHANGES; LITHIUM PROPHYLAXIS; MAJOR DEPRESSION; SUBSTANCE-ABUSE; MATERNAL-DEPRIVATION; NEUROTROPHIC FACTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Post, RM NIMH, Biol Psychiat Branch, 10 Ctr Dr,MSC 1272,Bldg 10,Room 3S239, Bethesda, MD 20892 USA NIMH 10 Ctr Dr,MSC 1272,Bldg 10,Room 3S239 Bethesda MD USA 20892
Citazione:
R.M. Post et al., "Developmental vulnerabilities to the onset and course of bipolar disorder", DEV PSYCHOP, 13(3), 2001, pp. 581-598

Abstract

Different types of psychosocial stressors have long been recognized as potential precipitants of both unipolar and bipolar affective episodes and thecausative agents in posttraumatic stress disorder (PTSD). New preclinical data have revealed some of the neurobiological mechanisms that could conveythe long-term behavioral and biochemical consequences of early stressors, Depending on the timing, quality, quantity, and degree of repetition. maternal deprivation stress in the neonatal rodent can be associated with lifelong anxiety-like behaviors, increases in stress hormones and peptides. and proneness to drug and alcohol administration, in association with acute changes in the rate of neurogenesis and apoptosis (preprogrammed cell death) and decrements in neurotrophic factors and signal transduction enzymes necessary for learning and memory. Patients with bipolar illness who have a history of early extreme adversity (physical or sexual abuse in childhood or adolescence), compared with those without, show an earlier onset of illness, faster cycling frequencies. increased suicidality, more Axis I and Axis II comorbidities (including alcohol and substance abuse), and more time ill in more than 2 years of prospective follow-up. These findings are subject to avariety of interpretations, but to the extent that the more severe course of bipolar illness characteristics are directly and causally related to these early stressful experiences, early recognition and treatment of high-risk children could be crucial in helping to prevent or ameliorate the long-term adverse consequences of these stressors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:01:08