Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of early stress on brain structure and function: Implications for understanding the relationship between child maltreatment and depression
Autore:
Kaufman, J; Charney, D;
Indirizzi:
Yale Univ, Dept Psychiat, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 , Dept Psychiat, New Haven, CT 06511 USA NIMH, Bethesda, MD USA NIMH Bethesda MD USANIMH, Bethesda, MD USA
Titolo Testata:
DEVELOPMENT AND PSYCHOPATHOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 451 - 471
SICI:
0954-5794(200122)13:3<451:EOESOB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; PREFRONTAL CORTICAL PROJECTIONS; RECURRENT MAJOR DEPRESSION; EARLY SOCIAL DEPRIVATION; CA3 PYRAMIDAL NEURONS; SEXUAL ABUSE; HIPPOCAMPAL VOLUME; MATERNAL SEPARATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufman, J Yale Univ, Dept Psychiat, Univ Towers,Suite 2H,100 York St, NewHaven, CT 06511 USA Yale Univ Univ Towers,Suite 2H,100 York St New Haven CT USA 06511
Citazione:
J. Kaufman e D. Charney, "Effects of early stress on brain structure and function: Implications for understanding the relationship between child maltreatment and depression", DEV PSYCHOP, 13(3), 2001, pp. 451-471

Abstract

Child abuse is associated with markedly elevated rates of major depression(MDD) in child. adolescent, and adult cohorts. This article reviews preclinical (e.g., animal) studies of the effects of early stress and studies of the neurobiological correlates of MDD in adults and children, and it highlights differences in the neurobiological correlates of MDD and stress at various developmental stages, The preclinical studies demonstrate that stress early in life can alter the development multiple neurotransmitter systems and promote structural and functional alterations in brain regions similar to those seen in adults with depression. Preclinical and clinical studies suggest, however, that long-term neurobiological changes associated with early stress can be modified by familial/genetic factors, the quality of the subsequent caregiving environment. and pharmacological interventions. Little is known about how developmental factors interact with experiences of earlystress and these other modifying factors. Moreover. in cases of child maltreatment, the effects of early abuse are often exacerbated by failures in the child protection system and repeat out-of-home placements. Given the number of factors that impact on the long-term outcome of maltreated children.multidisciplinary research efforts are recommended to address this problem-with foci that span from neurobiology to social policy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 07:02:28