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Titolo:
Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models
Autore:
Sanchez, MM; Ladd, CO; Plotsky, PM;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30303 USA Emory Univ Atlanta GA USA 30303 ychiat & Behav Sci, Atlanta, GA 30303 USA
Titolo Testata:
DEVELOPMENT AND PSYCHOPATHOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 419 - 449
SICI:
0954-5794(200122)13:3<419:EAEAAD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; MONKEYS MACACA-MULATTA; INFANT RHESUS-MONKEYS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CEREBROSPINAL-FLUID CONCENTRATIONS; CORTICOSTEROID RECEPTOR-BINDING; DEXAMETHASONE SUPPRESSION TEST; REGULATE POSTNATAL-DEVELOPMENT; EARLY ENVIRONMENTAL-REGULATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
232
Recensione:
Indirizzi per estratti:
Indirizzo: Sanchez, MM Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30303 USA Emory Univ Atlanta GA USA 30303 av Sci, Atlanta, GA 30303 USA
Citazione:
M.M. Sanchez et al., "Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models", DEV PSYCHOP, 13(3), 2001, pp. 419-449

Abstract

Increasing evidence supports the view that the interaction of perinatal exposure to adversity with individual genetic liabilities may increase an individual's vulnerability to the expression of psycho- and physiopathology throughout lifer The early environment appears to program some aspects of neurobiological development and. in turn. behavioral, emotional, cognitive, and physiological development. Several rodent and primate models of early adverse experience have been analyzed in this review, including those that "model" maternal separation or loss, abuse or neglect, and social deprivation. Accumulating evidence shows that these early traumatic experiences are associated with long-term alterations in coping style, emotional and behavioral regulation. neuroendocrine responsiveness to stress, social "fitness," cognitive function. brain morphology. neurochemistry, and expression levels of central nervous system genes that have been related to anxiety and mood disorders. Studies are underway to identify important aspects of adverse early experience. such as (a) the existence of "sensitive periods" during development associated with alterations in particular output systems, (b) the presence of "windows of opportunity" during which targeted interventions (e.g., nurturant parenting or supportive-enriching environment) may prevent orreverse dysfunction. (c) the identity of gene polymorphisms contributing to the individual's variability in vulnerability, and (d) a means to translate the timing of these developmental "sensitive periods" across species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:10:50