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Titolo:
Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus
Autore:
Forster, E; Zhao, ST; Frotscher, M;
Indirizzi:
Univ Freiburg, Inst Anat, D-79001 Freiburg, Germany Univ Freiburg Freiburg Germany D-79001 t Anat, D-79001 Freiburg, Germany
Titolo Testata:
DEVELOPMENT
fascicolo: 15, volume: 128, anno: 2001,
pagine: 3029 - 3039
SICI:
0950-1991(200108)128:15<3029:HACCFS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN SULFATE PROTEOGLYCAN; CAJAL-RETZIUS CELLS; ENTORHINAL CORTEX LESION; CENTRAL-NERVOUS-SYSTEM; ORGANOTYPIC SLICE COCULTURE; REELER MUTANT MICE; MOLECULE N-CAM; EXTRACELLULAR-MATRIX; NEURITE OUTGROWTH; FASCIA-DENTATA;
Keywords:
cell adhesion; hippocampus; entorhinal cortex; axon pathfinding; hyaluronan; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Forster, E Univ Freiburg, Inst Anat, POB 111, D-79001 Freiburg, Germany Univ Freiburg POB 111 Freiburg Germany D-79001 eiburg, Germany
Citazione:
E. Forster et al., "Hyaluronan-associated adhesive cues control fiber segregation in the hippocampus", DEVELOPMENT, 128(15), 2001, pp. 3029-3039

Abstract

In various brain regions, particularly in the hippocampus, afferent fiber projections terminate in specific layers. Little is known about the molecular cues governing this laminar specificity. To this end we have recently shown that the innervation pattern of entorhinal fibers to the hippocampus ismimicked by the lamina-specific adhesion of entorhinal cells on living hippocampal slices, suggesting a role of adhesion molecules in the positioningof entorhinal fibers. Here, we have analyzed the role of extracellular matrix components in mediating this lamina-specific adhesion. We show that hyaluronidase treatment of hippocampal slices abolishes lamina-specific adhesion as well as layer-specific growth of entorhinal fibers to the dentate outer molecular layer in organotypic slice cultures. We conclude that hyaluronan-associated molecules play a crucial role in the formation of the lamina-specific entorhinal projection to the hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:00:17