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Titolo:
Sleep deprivation as a model experimental antidepressant treatment: Findings from functional brain imaging
Autore:
Gillin, JC; Buchsbaum, M; Wu, J; Clark, C; Bunney, W;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92161 USA Univ Calif San Diego San Diego CA USA 92161 hiat, San Diego, CA 92161 USA VA San Diego Healthcare Syst, San Diego, CA 92161 USA VA San Diego Healthcare Syst San Diego CA USA 92161 n Diego, CA 92161 USA CUNY Mt Sinai Sch Med, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 h Med, New York, NY 10029 USA Univ Calif Irvine, Dept Psychiat, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 Dept Psychiat, Irvine, CA 92717 USA
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 37 - 49
SICI:
1091-4269(2001)14:1<37:SDAAME>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTERIZED-TOMOGRAPHY; SUBGENUAL PREFRONTAL CORTEX; CEREBRAL BLOOD-FLOW; DEPRESSED-PATIENTS; MAJOR DEPRESSION; PHASE ADVANCE; BIPOLAR DEPRESSION; MOOD DISORDERS; RAT-BRAIN; PSYCHOSTIMULANT THEORY;
Keywords:
PET; SPECT; FDG; HMPAO; anterior inglulate; major depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Gillin, JC Univ Calif San Diego, Dept Psychiat, 3350 La Jolla Village Dr, San Diego, CA 92161 USA Univ Calif San Diego 3350 La Jolla Village Dr San Diego CA USA 92161
Citazione:
J.C. Gillin et al., "Sleep deprivation as a model experimental antidepressant treatment: Findings from functional brain imaging", DEPRESS ANX, 14(1), 2001, pp. 37-49

Abstract

This paper reviews the functional brain imaging studies in depressed patients treated with sleep deprivation. Sleep deprivation is an excellent experimental,model of antidepressant treatments which offer new opportunities tounderstand the basic neural mechanisms. Its antidepressant effects are efficacious and rapid; sleep deprivation is easy to administer, inexpensive, and relatively safe; it can be studied in patients, normal controls, and animals; and it may lead to new treatments avid new paradigms for antidepressant therapies. Seven published papers, coming from five different research centers, using either positron emission tomography (PET) with (18)fluorodeoxyglucose (FDG) or single photon emission computerized tomography (SPECT) with Technetium-99-hexamethyl propyleneamine oxime (HMPAO) have relatively consistent findings. First, before sleep deprivation, responders have significantly elevated metabolism compared with non-responders, and usually the normal controls, in the orbital medial prefrontal cortex, and especially in the ventral portions of the anterior cingulate cortex. Secondly, after sleepdeprivation, these hyperactive areas normalize in the responders. The magnitude of the clinical improvement was significantly correlated with decreased local glucose metabolic rate or cerebral blood flow in three studies. The results are consistent with some but not all functional brain imaging studies of antidepressant medications in depressed patients. Finally, a SPECT study using a radioactively labeled D2 receptor antagonist suggests that the antidepressant benefits of sleep deprivation are correlated with endogenous release of dopamine. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:24:20