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Titolo:
Depression, sleep physiology, and antidepressant drugs
Autore:
Winokur, A; Gary, KA; Rodner, S; Rae-Red, C; Fernando, AT; Szuba, MR;
Indirizzi:
Univ Connecticut, Ctr Hlth, Dept Psychiat, Sch Med, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 ch Med, Farmington, CT 06030 USA Univ Penn, Dept Psychiat, Div Sleep & Chronobiol, Unit Expt Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA Univ Auckland, Sch Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland Auckland New Zealand 1 & Hlth Sci, Auckland 1, New Zealand
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 19 - 28
SICI:
1091-4269(2001)14:1<19:DSPAAD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED EVALUATION; REM-SLEEP; DOUBLE-BLIND; MAJOR DEPRESSION; EEG SLEEP; POLYGRAPHIC VARIABLES; ENDOGENOUS-DEPRESSION; INSOMNIAC PATIENTS; HEALTHY-SUBJECTS; CLINICAL STATE;
Keywords:
polysomnography; hypersomnia; REM; sleep stages; insomnia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Winokur, A Univ Connecticut, Ctr Hlth, Dept Psychiat, Sch Med, 263 Farmington Ave, Farmington, CT 06030 USA Univ Connecticut 263 Farmington Ave Farmington CT USA 06030 USA
Citazione:
A. Winokur et al., "Depression, sleep physiology, and antidepressant drugs", DEPRESS ANX, 14(1), 2001, pp. 19-28

Abstract

This review summarizes current findings regarding effects of antidepressant compounds on sleep architecture and interprets their clinical relevance. Effects of the major classes of antidepressant drugs on sleep properties are presented, with the antidepressant compounds organized into categories based primarily on their putative mechanism of action. The majority of antidepressant compounds, across several different categories, exhibit robust suppression of PEM sleep. Others, such as bupropion and nefazodone, lack PEM suppressant effects. Such findings support the idea that critical neurochemical mechanisms involved in the regulation of discrete sleep stages can be elucidated by means of polysomnographic investigations utilizing pharmacologically targeted agents. Clinicians have appreciated the importance of antidepressant drug effects on sleep when considering therapeutic options for patients. While such decisions in the past were based on empirical observations, an increasing amount of information regarding specific effects of different antidepressant drugs on sleep continuity and sleep architecture is available. Thus, clinicians ma choose to consider profiles of sleep effects for different antidepressant drugs in the initial selection of an antidepressant compound. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:45:23