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Titolo:
Phagocyte-mediated oxidation in idiosyncratic adverse drug reactions
Autore:
Rubin, RL; Kretz-Rommel, A;
Indirizzi:
Scripps Clin & Res Inst, Dept Mol & Expt Med, Keck Autoimmune Dis Ctr, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 Ctr, La Jolla, CA 92037 USA
Titolo Testata:
CURRENT OPINION IN HEMATOLOGY
fascicolo: 1, volume: 8, anno: 2001,
pagine: 34 - 40
SICI:
1065-6251(200101)8:1<34:POIIAD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; LYMPH-NODE ASSAY; HUMAN-NEUTROPHILS; T-CELLS; ACTIVATED NEUTROPHILS; COVALENT BINDING; INDUCED LUPUS; MYELOPEROXIDASE SYSTEM; INDUCED AGRANULOCYTOSIS; IN-VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Rubin, RL Scripps Clin & Res Inst, Dept Mol & Expt Med, Keck Autoimmune Dis Ctr, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
R.L. Rubin e A. Kretz-Rommel, "Phagocyte-mediated oxidation in idiosyncratic adverse drug reactions", CURR OPIN H, 8(1), 2001, pp. 34-40

Abstract

The drug-metabolizing capacity of the liver is well known but cannot account for most idiosyncratic adverse drug reactions. Of the extrahepatic sources of reactive drug metabolites, the neutrophil has received the most attention because of its vast numbers and robust oxidizing machinery. Many drugsassociated with autoimmunity are susceptible to oxidative transformation by the enzymatic action of myeloperoxidase, a protein released into the extracellular environment when neutrophils are activated. Production of the resulting drug metabolites within lymphoid organs maximizes their immune-perturbing effects. Mechanisms proposed for the initiation of drug-induced blooddyscrasias, hypersensitivity reactions, or lupus-like symptoms center around three views: (1) presentation of the implicated compound in the major histocompatibility complex of antigen-presenting cells via direct binding or after processing as a hapten bound to self-macromolecules, (2) direct cytotoxicity, or (3) interference in the development of T-cell tolerance in the thymus. How participation of reactive drug metabolites in these processes might lead to symptomatic disease is discussed. (C) 2001 Lippincott Williams& Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:46:03