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Titolo:
Eosinophil granule proteins and their role in disease
Autore:
Walsh, GM;
Indirizzi:
Univ Aberdeen, Sch Med, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland Univ Aberdeen Aberdeen Scotland AB25 2ZD ut, Aberdeen AB25 2ZD, Scotland
Titolo Testata:
CURRENT OPINION IN HEMATOLOGY
fascicolo: 1, volume: 8, anno: 2001,
pagine: 28 - 33
SICI:
1065-6251(200101)8:1<28:EGPATR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; MAJOR BASIC-PROTEIN; CATIONIC PROTEIN; MATRIX METALLOPROTEINASE-9; AIRWAY HYPERRESPONSIVENESS; EPITHELIAL-CELLS; INDUCED ASTHMA; DEGRANULATION; INFLAMMATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Walsh, GM Univ Aberdeen, Sch Med, Dept Med & Therapeut, IMS Bldg, AberdeenAB25 2ZD,Scotland Univ Aberdeen IMS Bldg Aberdeen Scotland AB25 2ZD 2ZD,Scotland
Citazione:
G.M. Walsh, "Eosinophil granule proteins and their role in disease", CURR OPIN H, 8(1), 2001, pp. 28-33

Abstract

The eosinophil has a potent armory of proinflammatory mediators with considerable potential to initiate and sustain an inflammatory response. These Include cytotoxic granule proteins, cytokines, chemokines, and lipid mediators. Eosinophils are considered important in the immune response to infection with helminthic parasitic worms. Incrementally increasing evidence supports a critical role for their proinflammatory activities in diverse human conditions, most notably in allergic diseases such as asthma. In these conditions severe tissue damage is a consequence of an inappropriate accumulationof eosinophils and the subsequent release of their highly toxic granule proteins. In addition, release of granute-associated products such as chemokines and cytokines at the sites of inflammation is likely to have significant paracrine and autocrine relevance. This review will update recent developments in understanding the role that eosinophil granule proteins play in human disease, particularly those of the respiratory tract. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:46:54