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Titolo:
The inhibitory neural circuitry as target of antiepileptic drugs
Autore:
Bohme, I; Luddens, H;
Indirizzi:
Univ Mainz, Clin Res Grp, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 11, volume: 8, anno: 2001,
pagine: 1257 - 1274
SICI:
0929-8673(200109)8:11<1257:TINCAT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; GABA UPTAKE INHIBITORS; TEMPORAL-LOBE EPILEPSY; PLASMA-MEMBRANE TRANSPORTER; PANCREATIC BETA-CELLS; RAT-BRAIN; HIGH-AFFINITY; GLYCINE TRANSPORTER; ANTICONVULSANT ACTIVITY; RECEPTOR ANTAGONISTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
135
Recensione:
Indirizzi per estratti:
Indirizzo: Bohme, I Univ Mainz, Clin Res Grp, Dept Psychiat, Untere Zahlbacher Str 8,D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55131 Germany
Citazione:
I. Bohme e H. Luddens, "The inhibitory neural circuitry as target of antiepileptic drugs", CURR MED CH, 8(11), 2001, pp. 1257-1274

Abstract

Impairments and defects in the inhibitory neurotransmission in the CNS cancontribute to various seizure disorders, i.e., gamma -aminobutyric acid (GABA) and glycine as the main inhibitory neurotransmitters in the brain playa crucial role in some forms of epilepsy. Recent advances in deciphering the molecular basis of the GABAergic and glycinergic systems has been achieved by means of cloning techniques and gene targeting strategies in animals,contributing to the understanding of drug action. As well, several anticonvulsive substances emerged which target key molecules of the inhibitory systems. Employment of recombinant expression systems, including, but not restricted to the inhibitory circuitry, will further facilitate drug screening and rational approaches to design novel specific antiepileptic drugs, whichact highly efficiently to prevent or reduce generation and spread of seizures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:21:02