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Titolo:
Glomerular permeability after surgical trauma in children: Relationship between microalbuminuria and surgical stress score
Autore:
Sarti, A; De Gaudio, AR; Messineo, A; Cuttini, M; Ventura, A;
Indirizzi:
Res & Care Childrens Hosp, IRCCS Burio Garofolo, Dept Anesthesia & Intens Care, Trieste, Italy Res & Care Childrens Hosp Trieste Italy a & Intens Care, Trieste, Italy Res & Care Childrens Hosp, IRCCS Burio Garofolo, Dept Pediat, Trieste, Italy Res & Care Childrens Hosp Trieste Italy lo, Dept Pediat, Trieste, Italy Res & Care Childrens Hosp, IRCCS Burio Garofolo, Dept Pediat Surg, Trieste, Italy Res & Care Childrens Hosp Trieste Italy ept Pediat Surg, Trieste, Italy Res & Care Childrens Hosp, IRCCS Burio Garofolo, Epidemiol Unit, Trieste, Italy Res & Care Childrens Hosp Trieste Italy Epidemiol Unit, Trieste, Italy Univ Florence, Inst Anesthesiol & Crit Care Med, Florence, Italy Univ Florence Florence Italy esthesiol & Crit Care Med, Florence, Italy Univ Trieste, I-34127 Trieste, Italy Univ Trieste Trieste Italy I-34127Univ Trieste, I-34127 Trieste, Italy
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 8, volume: 29, anno: 2001,
pagine: 1626 - 1629
SICI:
0090-3493(200108)29:8<1626:GPASTI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY; SEVERITY; PROTEINURIA; PREDICTOR; DISEASE; INJURY;
Keywords:
microalbuminuria; albumin; albumin creatinine ratio; pediatrics; child; glomerular permeability; capillary permeability; vascular permeability; systemic inflammatory response; surgery; surgical trauma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sarti, A IRCCS Burlo Garofolo, Via Istria 65-1, I-34137 Trieste, Italy IRCCS Burlo Garofolo Via Istria 65-1 Trieste Italy I-34137 Italy
Citazione:
A. Sarti et al., "Glomerular permeability after surgical trauma in children: Relationship between microalbuminuria and surgical stress score", CRIT CARE M, 29(8), 2001, pp. 1626-1629

Abstract

Objectives. To determine whether there is an increase of urinary albumin during and after surgical trauma and investigate a possible relationship between microalbuminuria and the severity of surgical stress. Design: Prospective study. Setting. University hospital pediatric intensive care unit. Patients: Forty consecutive children scheduled for elective surgery. Interventions. None. Measurements and Main Results: Microalbuminuria/urinary creatinine ratio (MACR) was measured before, during, and after elective moderate or major surgical procedures. The Oxford Surgical Stress Score (SSS) was determined foreach patient at the end of the operation, and its relationship with maximum deviation of MAGR from baseline values was investigated. MACR showed a progressive increase during surgery and a decrease afterward, reaching preoperative values in most cases within 24 hrs after the end of surgery. There was a significant correlation between the increase in MAGR and severity of the surgical trauma as measured by SSS. Two patients showed a rise in MACR after the initial postoperative normalization before clinical appearance of a Sur gical complication and one patient showed a persistent rise in MACR before clinical appearance of a septic complication. None of the other patients showed any rise in MACR after postoperative normalization, and they allhad an uneventful recovery. Conclusions. MACR rises during and after major or moderate elective surgery in children. There is a significant positive correlation between severityof surgical trauma and capillary permeability in pediatric patients. Microalbuminuria, as an index of capillary permeability, may be an early sign ofincipient complications and assist in the identification of those patientswhose condition will deteriorate. The test is a cheap, blood-sparing, easy-to-perform bedside procedure that may have a useful role in clinical practice for evaluating the effect of surgical trauma on capillary permeability in children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:10:50