Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Timing of the appearance of multipotential and committed haemopoietic progenitors in peripheral blood after mobilization in patients with lymphoma
Autore:
Hepburn, MD; Nagesh, K; Heppleston, AD; Cachia, PG; Pippard, MJ;
Indirizzi:
Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland Univ Dundee Dundee Scotland DD1 9SY lar Pathol, Dundee DD1 9SY, Scotland
Titolo Testata:
CLINICAL AND LABORATORY HAEMATOLOGY
fascicolo: 2, volume: 23, anno: 2001,
pagine: 119 - 124
SICI:
0141-9854(200104)23:2<119:TOTAOM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; HEMATOPOIETIC-CELLS; INVITRO; INTERLEUKIN-3;
Keywords:
peripheral blood stem cells; CFU-A; CFU-GM; BFU-E; lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Hepburn, MD Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland Univ Dundee Dundee Scotland DD1 9SY Dundee DD1 9SY, Scotland
Citazione:
M.D. Hepburn et al., "Timing of the appearance of multipotential and committed haemopoietic progenitors in peripheral blood after mobilization in patients with lymphoma", CLIN LAB H, 23(2), 2001, pp. 119-124

Abstract

The pattern of emergence of multipotential (CFU-A) and committed (CFU-GM and BFU-E) progenitor cells in peripheral blood has been examined in patients with Hodgkin's disease and non-Hodgkin's lymphoma. Mobilization protocolsused chemotherapy with or without granulocyte colony-stimulating factor (n=8 and n=5, respectively). In all patients, the numbers of CFU-A. CFU-GM and BFU-E peaked simultaneously, rather than sequentially, suggesting that marrow regeneration after these mobilization protocols occurred from progenitors at all stages of differentiation. We conclude that peripheral blood stem cell harvest strategies based on peak values for total progenitor numberswill also capture maximum numbers of multipotential progenitors. However, the variable relationship between CFU-A and CFU-GM numbers suggests that overall progenitor cell numbers can give only a broad estimate of the absolute numbers of multipotential progenitors in an individual harvest.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 18:07:44