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Titolo:
Expression of costimulatory CD80/CD86-CD28/CD152 molecules in nasal mucosaof patients with perennial allergic rhinitis
Autore:
Hattori, H; Okano, M; Yoshino, T; Akagi, T; Nakayama, E; Saito, C; Satoskar, AR; Ogawa, T; Azuma, M; Nishizaki, K;
Indirizzi:
Okayama Univ, Sch Med, Dept Otolaryngol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 t Otolaryngol, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Pathol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Pathol, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Immunol & Parasitol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 l & Parasitol, Okayama 7008558, Japan Okayama Municipal Hosp, Dept Otolaryngol, Okayama, Japan Okayama MunicipalHosp Okayama Japan , Dept Otolaryngol, Okayama, Japan Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 munol & Infect Dis, Boston, MA 02115 USA Tokyo Med & Dent Univ, Grad Sch, Dept Mol Immunol, Div Oral Hlth Sci, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan unol, Div Oral Hlth Sci, Tokyo, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 8, volume: 31, anno: 2001,
pagine: 1242 - 1249
SICI:
0954-7894(200108)31:8<1242:EOCCMI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL PROLIFERATION; UP-REGULATION; B-CELLS; ACTIVATION ANTIGEN; IMMUNE-RESPONSE; B7-2; CD86; INDUCTION; CTLA-4; CD28;
Keywords:
costimulatory molecules; nasal mucosa; allergic rhinitis; nasal provocation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Okano, M Okayama Univ, Sch Med, Dept Otolaryngol, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8558, Japan
Citazione:
H. Hattori et al., "Expression of costimulatory CD80/CD86-CD28/CD152 molecules in nasal mucosaof patients with perennial allergic rhinitis", CLIN EXP AL, 31(8), 2001, pp. 1242-1249

Abstract

Background B7 molecules (CD80, CD86) and their counter-receptors, CD28 andCD152 (CTLA-4), play an important role, in T cell-mediated immune responses. We previously demonstrated that B7 molecules are selectively up-regulated not only on B cells but also on T cells from the peripheral blood mononuclear cells of patients with perennial rhinitis cultured with allergen. However, the expression of CD80/CD86 molecules and their counter-receptors in nasal mucosa, the actual inflammatory site of allergic rhinitis, has not yetbeen clarified. Patients and methods Inferior turbinates from patients with either allergyto house dust or non-allergic rhinitis were excised and immunohistologically stained. In addition, the inferior turbinates were challenged with paperdiscs containing extracts of house dust and subsequently excised. Samples were double stained with immunofluorescent-labelled antibody to identify cells bearing CD86. Results Without the nasal provocation, only the expression of CD86 was increased in nasal mucosa of patients with allergic rhinitis compared with those with non-allergic rhinitis. However, following the nasal provocation with house dust, not only CD86, but also CD80, CD28, and CD152 were, significantly expressed in allergic patients. Immunofluorescent double staining revealed CD86 expression in CD19, CD1a, CD14 and CD3 lymphocytes. Conclusion These results indicate that the expression of CD80/CD86 molecules and their counter-receptors is induced in allergic patients following nasal provocation with allergen, suggesting a local amplification of allergen-specific immune responses in perennial rhinitis.

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Documento generato il 14/07/20 alle ore 04:55:35