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Titolo:
Validation of germination rate and root elongation as indicator to assess phytotoxicity with Cucumis sativus
Autore:
Wang, XD; Sun, C; Gao, SX; Wang, LS; Han, SK;
Indirizzi:
Nanjing Univ, Dept Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Nanjing 210093, Peoples R China Nanjing Univ Nanjing PeoplesR China 210093 jing 210093, Peoples R China
Titolo Testata:
CHEMOSPHERE
fascicolo: 8, volume: 44, anno: 2001,
pagine: 1711 - 1721
SICI:
0045-6535(200109)44:8<1711:VOGRAR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE STRUCTURE-ACTIVITY; LETTUCE FRUIT GERMINATION; TETRAHYMENA-PYRIFORMIS; PHENOLIC-COMPOUNDS; TOXICITY; INHIBITION; PIMEPHALES; TOXICOLOGY; MECHANISM; ANILINES;
Keywords:
QSAR; phenols and anilines; mode of action;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, LS Nanjing Univ, Dept Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Nanjing 210093, Peoples R China Nanjing Univ Nanjing Peoples R China 210093 93, Peoples R China
Citazione:
X.D. Wang et al., "Validation of germination rate and root elongation as indicator to assess phytotoxicity with Cucumis sativus", CHEMOSPHERE, 44(8), 2001, pp. 1711-1721

Abstract

Germination rate and root elongation, as a rapid phytotoxicity test method, possess several advantages, such as sensitivity, simplicity, low cost andsuitability for unstable chemicals or samples. These advantages made them suitable for developing a large-scale phytotoxicity database and especiallyapplicable for developing quantitative structure-activity relationship (QSAR) to study mechanisms of phytotoxicity. In this paper, the comparative inhibition of germination rate and root elongation of Cucumis sativus by selected halogen-substituted phenols and anilines were determined. The suitability of germination rate and root elongation as phytotoxicity endpoints was evaluated. Excellent reproducibility and stability of germination rate and root elongation in the control test, relatively greater sensitivity and similar dose-response relations for all tested compounds were observed. These results together with those of a 2-day test were used to demonstrate the suitability of this phytotoxicity test method. A QSAR was developed for the phytotoxicity mode of action of the tested compounds to C. sativus seeds. Models that combined the logarithm of 1-octanol/water partition coefficient (log K-ow) and the energy of the lowest unoccupied molecular orbital (E-lumo) were developed for both germination rate inhibition and root elongation inhibition. The results of these studies indicate that phytotoxicity of substituted phenols and anilines to C. sativus seeds could be explained by a polar narcosis mechanism. This paper will promote the application of germination rate and root elongation method and the development of large-scale phytotoxicity database, which will provide the fundamental data for QSAR and ecological risk assessment of organic pollutants. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 07:49:07