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Titolo:
The neurotrophic factors in non-neuronal tissues
Autore:
Sariola, H;
Indirizzi:
Univ Helsinki, Inst Biotechnol, Dev Biol Res Program, Helsinki 00014, Finland Univ Helsinki Helsinki Finland 00014 es Program, Helsinki 00014, Finland
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 8, volume: 58, anno: 2001,
pagine: 1061 - 1066
SICI:
1420-682X(200107)58:8<1061:TNFINT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; LEUKEMIA INHIBITORY FACTOR; MICE LACKING GDNF; HEPATIC STELLATE CELLS; AFFINITY NGF RECEPTOR; EMBRYONIC STEM-CELLS; TYROSINE KINASE; MESSENGER-RNA; KIDNEY MORPHOGENESIS; NONNEURAL TISSUES;
Keywords:
neurotrophic factor; GDNF; neurotrophin; interleukin-6; kidney; testis; lymphocyte; mast cell; liver;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Sariola, H Univ Helsinki, Inst Biotechnol, Dev Biol Res Program, POB 56, Helsinki 00014, Finland Univ Helsinki POB 56 Helsinki Finland 00014 nki 00014, Finland
Citazione:
H. Sariola, "The neurotrophic factors in non-neuronal tissues", CELL MOL L, 58(8), 2001, pp. 1061-1066

Abstract

Although neurotrophic factors are defined as molecules that maintain neuronal cells, they possess a range of functions outside the nervous system. For example, glial cell line-derived neurotrophic factor is essential for ureteric branching in kidney morphogenesis and for regulating the fate of stemcells during spermatogenesis. Leukemia inhibitory factor, a member of the interleukin-6 (IL-6) ciliary neurotrophic factor family, inhibits differentiation of embryonic stem cells, induces tubulogenesis in the embryonic kidney, and regulates sperm differentiation. Other IL-6 family members are important in cardiac differentiation and they have pleiotropic functions in thehematopoietic and immune systems. Although neurotrophin receptors have been found on a number of non-neuronal tissues, they represent mostly truncated receptor isoforms that are incapable of signal transduction and may have scavenger or dominant negative functions. However, several examples can be presented of essential non-neuronal functions played by neurotrophins in e.g., cardiac, hair follicle, and vascular differentiation, and the maintenance of immune cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:18:35