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Titolo:
Receptor binding, internalization, and retrograde transport of neurotrophic factors
Autore:
Neet, KE; Campenot, RB;
Indirizzi:
Finch Univ Hlth Sci Chicago Med Sch, Dept Biochem & Mol Biol, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 , IL 60064 USA Univ Alberta, Dept Cell Biol, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 iol, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 8, volume: 58, anno: 2001,
pagine: 1021 - 1035
SICI:
1420-682X(200107)58:8<1021:RBIART>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RAT SYMPATHETIC NEURONS; AFFINITY NGF RECEPTOR; LEUKEMIA INHIBITORY FACTOR; TRK PROTOONCOGENE PRODUCT; LEUCINE-RICH MOTIF; SIGNAL TRANSDUCING RECEPTOR; IMMUNOGLOBULIN-LIKE DOMAINS; TYROSINE KINASE RECEPTOR; PC12 CELLS;
Keywords:
neurotrophin; neurotrophic factor; nerve growth factor (NGF); glial cell-derived neurotrophic factor (GDNF); ciliary neurotrophic factor (CNTF); retrograde transport; receptor; Trk; cRet;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
150
Recensione:
Indirizzi per estratti:
Indirizzo: Neet, KE Finch Univ Hlth Sci Chicago Med Sch, Dept Biochem & Mol Biol, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 4 USA
Citazione:
K.E. Neet e R.B. Campenot, "Receptor binding, internalization, and retrograde transport of neurotrophic factors", CELL MOL L, 58(8), 2001, pp. 1021-1035

Abstract

This review deals with the receptor interactions of neurotrophic factors, focusing on the neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic factor (GDNF) family, and the ciliary neurotrophic factor (CNTF) family. The finding that two proteins, p75(NTR) and Trk, act as receptors for NGF in neurons generated the discovery of other neurotrophic factors/receptor families and has enhanced our understanding of the development, survival, regeneration, and degeneration of the nervous system. The kinetics of binding, the structure of the ligand-receptor complex, and the mechanism of retrograde transport of the neurotrophins are discussed in detail and compared to information available on the GDNF and CNTF families. Each neurotrophic factor family, i.e., NGF, GDNF, and CNTF, has a set of receptors with specificity for individual members of the family and acommon receptor without member specificity that, in some families, generates the cellular signal and retrograde transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:31:18