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Titolo:
Progesterone-induced increase of sperm cytosolic calcium is enhanced by previous fusion of spermatozoa to prostasomes
Autore:
Arienti, G; Nicolucci, A; Santi, F; Carlini, E; Palmerini, CA;
Indirizzi:
Dept Internal Med, Biochem Lab, I-06127 Perugia, Italy Dept Internal Med Perugia Italy I-06127 chem Lab, I-06127 Perugia, Italy Dept Mol & Cellular Biol, Perugia, Italy Dept Mol & Cellular Biol Perugia Italy & Cellular Biol, Perugia, Italy
Titolo Testata:
CELL CALCIUM
fascicolo: 3, volume: 30, anno: 2001,
pagine: 222 - 227
SICI:
0143-4160(200109)30:3<222:PIOSCC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE PHOSPHORYLATION; PLASMA PREVENTS SPERM; ACROSOME REACTION; SEMINAL PLASMA; IN-VITRO; CHOLESTEROL; CAPACITATION; MEMBRANES; RECEPTOR; RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Arienti, G Dept Internal Med, Biochem Lab, Via del Giochetto, I-06127 Perugia, Italy Dept Internal Med Via del Giochetto Perugia Italy I-06127 taly
Citazione:
G. Arienti et al., "Progesterone-induced increase of sperm cytosolic calcium is enhanced by previous fusion of spermatozoa to prostasomes", CELL CALC, 30(3), 2001, pp. 222-227

Abstract

Ejaculated spermatozoa must undergo a number of modifications before becoming able to fertilize the oocyte. The interaction of sperm with other semencomponents may influence these phenomena; human semen contains vesicles ofprostatic origin, called prostasomes that may fuse to sperm at slightly acidic to neutral pH values. Prostasomes contain calcium and it has been demonstrated that their fusion with spermatozoa produces a transient increase (wave) of [Ca2+](i) in these cells. The fusion process also transfers protein and lipid to spermatozoa. These phenomena may induce long-lasting changesof sperm properties. We test the hypothesis that spermatozoa, as modified by fusion, change their ability to undergo the progesterone-induced increase of [Ca2+](i) and wefind that the increase of [Ca2+](i) produced by the fusion with prostasomes and by the stimulation with progesterone are independent and additive phenomena. We also find that spermatozoa present a stronger response to the progesterone-induced increase of [Ca2+](i) if they are previously made to fuse with prostasomes. This effect does not depend directly on the [Ca2+](i) increase due to fusion, since it is still present after the [Ca2+](i) has returned to resting values. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:30:40