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Titolo:
p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo
Autore:
Yang, WC; Velcich, A; Mariadason, J; Nicholas, C; Corner, G; Houston, M; Edelmann, W; Kucherlapati, R; Holt, PR; Augenlicht, LH;
Indirizzi:
Montefiore Med Ctr, Albert Einstein Canc Ctr, Dept Oncol, Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 tr, Dept Oncol, Bronx, NY 10467 USA Albert Einstein Canc Ctr, Dept Cell Biol, Bronx, NY 10467 USA Albert Einstein Canc Ctr Bronx NY USA 10467 ell Biol, Bronx, NY 10467 USA Albert Einstein Canc Ctr, Dept Mol Genet, Bronx, NY 10467 USA Albert Einstein Canc Ctr Bronx NY USA 10467 ol Genet, Bronx, NY 10467 USA St Lukes Roosevelt Hosp, Dept Med, New York, NY 10025 USA St Lukes Roosevelt Hosp New York NY USA 10025 Med, New York, NY 10025 USA Columbia Univ, New York, NY 10025 USA Columbia Univ New York NY USA 10025Columbia Univ, New York, NY 10025 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 16, volume: 61, anno: 2001,
pagine: 6297 - 6302
SICI:
0008-5472(20010815)61:16<6297:PIAIDO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; COLONIC-CARCINOMA CELLS; CYCLIN-DEPENDENT KINASES; CHAIN FATTY-ACIDS; BETA-CATENIN; TUMOR SUPPRESSION; SODIUM-BUTYRATE; CANCER CELLS; C-MYC; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Augenlicht, LH Montefiore Med Ctr, Albert Einstein Canc Ctr, Dept Oncol, 111 E 210th St, Bronx, NY 10467 USA Montefiore Med Ctr 111 E 210th St Bronx NY USA 10467 67 USA
Citazione:
W.C. Yang et al., "p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo", CANCER RES, 61(16), 2001, pp. 6297-6302

Abstract

Sulindac, a nonsteroidal anti-inflammatory drug, inhibits intestinal tumorigenesis in humans and rodents. Sulindac induced complex alterations in gene expression, but only 0.1% of 8063 sequences assayed were altered similarly by the drug in rectal biopsies or patients treated for 1 month and duringresponse of colonic cells in culture. Among these changes was induction ofthe cyclin-dependent kinase inhibitor, p21(WAF1/cip1). In Apc1638(+/-) mice, targeted inactivation of p21 increased intestinal tumor formation in a gene-dose-dependent manner, but inactivation of p21 completely eliminated the ability of sulindac to both inhibit mitotic activity in the duodenal mucosa and to inhibit Ape-initiated tumor formation. Thus, p21 is essential fortumor inhibition by this drug. The array data can be accessed on the Internet at http://Sequence.accom.yu. edu/genome/.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:32:52