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Titolo:
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine
Autore:
Hagiwara, A; Miyashita, K; Nakanishi, T; Sano, M; Tamano, S; Kadota, T; Koda, T; Nakamura, M; Imaida, K; Ito, N; Shirai, T;
Indirizzi:
Daiyu Kai Inst Med Sci, Nishiazai, Ichinomiya 4910113, Japan Daiyu Kai Inst Med Sci Nishiazai Ichinomiya Japan 4910113 4910113, Japan Nagoya City Univ, Sch Med, Dept Pathol 1, Mizuho Ku, Nagoya, Aichi 4670001, Japan Nagoya City Univ Nagoya Aichi Japan 4670001 Nagoya, Aichi 4670001, Japan San Ei Gen FFI Inc, Toyonaka, Osaka 5618588, Japan San Ei Gen FFI Inc Toyonaka Osaka Japan 5618588 aka, Osaka 5618588, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 171, anno: 2001,
pagine: 17 - 25
SICI:
0304-3835(20010928)171:1<17:PIBANA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABERRANT CRYPT FOCI; HETEROCYCLIC AMINES; POLYETHYLENE-GLYCOL; TUMOR-INCIDENCE; COOKED FOODS; IN-VITRO; CANCER; AZOXYMETHANE; CHEMOPREVENTION; PHIP;
Keywords:
anthocyanin; purple corn color; colorectal carcinogenesis; F344 rats; inhibition; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; 1,2-dimethylhydrazine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Hagiwara, A Daiyu Kai Inst Med Sci, 64 Goura, Nishiazai, Ichinomiya 4910113, Japan Daiyu Kai Inst Med Sci 64 Goura Nishiazai Ichinomiya Japan 4910113
Citazione:
A. Hagiwara et al., "Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine", CANCER LETT, 171(1), 2001, pp. 17-25

Abstract

The potential of purple corn color (PCC), a natural anthocyanin, to modifycolorectal carcinogenesis was investigated in male F344/DuCrj rats, initially treated with 1,2-dimethylhydrazine (DMH), receiving 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the diet. After DMH initiation, PCC was given at a dietary level of 5.0% in combination with 0.02% PhIP until week 36. No PCC-treatment-related changes in clinical signs, body weight andfood consumption were found. Incidences and multiplicities of colorectal adenomas and carcinomas in rats initiated with DMH were clearly increased byPhIP. In contrast, lesion development was suppressed by PCC administration. Furthermore, in the non-DMH initiation groups, induction of aberrant crypt foci by PhIP tended to be decreased by the PCC supplementation. The results thus demonstrate that while PhIP clearly exerts promoting effects on DMH-induced colorectal carcinogenesis, these can be reduced by 5.0% PCC in thediet, under the present experimental conditions. (C) 2001 Elsevier ScienceIreland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:55:27