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Titolo:
The immune anti-tumor effects of GM-CSF and B7-1 gene transfection are enhanced by surgical debulking of tumor
Autore:
Mukherjee, S; Nelson, D; Loh, S; van Bruggen, I; Palmer, LJ; Leong, C; Garlepp, MJ; Robinson, BWS;
Indirizzi:
Univ Western Australia, Dept Med, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia Curtin Univ Technol, Dept Pharm, Perth, WA 6001, Australia Curtin Univ Technol Perth WA Australia 6001 rm, Perth, WA 6001, Australia Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA Brigham & WomensHosp Boston MA USA 02115 nning Lab, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA DNAX Res Inst, Palo Alto, CA USA DNAX Res Inst Palo Alto CA USADNAX Res Inst, Palo Alto, CA USA Western Australian Inst Med Res, Perth, WA, Australia Western Australian Inst Med Res Perth WA Australia Perth, WA, Australia
Titolo Testata:
CANCER GENE THERAPY
fascicolo: 8, volume: 8, anno: 2001,
pagine: 580 - 588
SICI:
0929-1903(200108)8:8<580:TIAEOG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT PLEURAL MESOTHELIOMA; COLONY-STIMULATING FACTOR; DENDRITIC CELLS; MULTIMODALITY THERAPY; PHASE-II; GENERATION; EXPRESSION; PLEURECTOMY/DECORTICATION; IMMUNOSUPPRESSION; VACCINATION;
Keywords:
gene therapy; debulking surgery; malignant mesothelioma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Mukherjee, S Harvard Univ, Sch Publ Hlth, Occupat Hlth Program, Bldg 1,Room 1402,665 Huntington Ave, Boston, MA 02115 USA Harvard Univ Bldg 1,Room 1402,665 Huntington Ave Boston MA USA 02115
Citazione:
S. Mukherjee et al., "The immune anti-tumor effects of GM-CSF and B7-1 gene transfection are enhanced by surgical debulking of tumor", CANC GENE T, 8(8), 2001, pp. 580-588

Abstract

Malignant mesothelioma (MM) is a solid tumor largely unresponsive to conventional therapies. Immunological gene therapy shows promise in murine models and human clinical trials; however, the role of surgery in combination with gone therapy has not been widely studied. The aim of this study was to determine if debulking surgery improved the effectiveness of gene therapy ina murine MM model. Mice were subcutaneously inoculated with the MM cell line, AC29, at two different sites, 4 clays apart, to allow a surgical and distal site tumor to develop. Once tumors were established, the surgical sitetumor was debulked and vaccination of syngeneic tumor transfectants encoding genes for IL-4, IL-2, GM-CSF, B7-1 or allogeneic MHC molecules commencedat a site away from both tumors, and tumor growth was measured. Neither debulking surgery nor gene therapy alone delayed tumor growth. However, therewas a clear delay of tumor growth when debulking surgery was combined withvaccination of tumor transfectants expressing B7-1 or high levels of GM-CSF. Combinations of these two transfectants (lid not lead to a synergistic effect. This study demonstrates that debulking surgery can augment the immunostimulatory effects of immunological gene therapy and can delay tumor growth. This has implications for the future design of human gene therapy trials for solid tumors such as MM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:01:54