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Titolo:
Fragment-specific actions of parathyroid hormone in isolated perfused rat hearts
Autore:
Shimoyama, M; Ogino, K; Uchida, K; Furuse, Y; Kinugasa, Y; Taniguchi, S; Igawa, O; Hisatome, I; Bilezikian, JP; Shigemasa, C;
Indirizzi:
Tottori Univ, Fac Med, Dept Med, Div Cardiol, Yonago, Tottori 6838504, Japan Tottori Univ Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan Columbia Univ Coll Phys & Surg, Dept Med & Pharmacol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
CALCIFIED TISSUE INTERNATIONAL
fascicolo: 2, volume: 69, anno: 2001,
pagine: 88 - 93
SICI:
0171-967X(200108)69:2<88:FAOPHI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ACTIVATION DOMAIN; HEMODYNAMIC BASIS; CELLS; RECEPTOR; PEPTIDE; OSTEOBLASTS; INCREASES; CALCIUM; PTH;
Keywords:
fragment; parathyroid hormone; heart; chronotropy; vasodilatation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ogino, K Tottori Univ, Fac Med, Dept Med, Div Cardiol, 36-1 Nishimachi, Yonago, Tottori 6838504, Japan Tottori Univ 36-1 Nishimachi Yonago Tottori Japan 6838504 , Japan
Citazione:
M. Shimoyama et al., "Fragment-specific actions of parathyroid hormone in isolated perfused rat hearts", CALCIF TIS, 69(2), 2001, pp. 88-93

Abstract

Different regions within the parathyroid hormone (PTH) molecule are known to have different biological activities. In the heart. the physiological actions of the intact PTH molecule are known as positive chronotropy and coronary vasodilatation. However, it is unclear which region of the PTH exerts which physiological action in the heart. Therefore, to clarify this point, we examined the hemodynamic effect of intact PTH(1-84) and selected PTH analogs, namely, PTH(1-34), PTH(2-34), [Nle8, 18Tyr34]PTH(3-34), PTH(4-34), [Tyr34]PTH(7-34), and PTH(13-34) in isolated perfused rat hearts. Both PTH(1-84) and PTH(1-34) significantly increased heart rate and decreased coronaryperfusion pressure. In contrast, neither PTH(2-34) nor [Nle8,18Tyr34]PTH(3-34) increased heart rate, but they did decrease coronary perfusion pressure. Peptides further truncated at the amino terminus, PTH(4-34), [Tyr34]PTH(7-34), and PTH(13-34), had no effect on hemodynamics. Furthermore, the protein kinase A inhibitor H89, but not the protein kinase C inhibitor H7. attenuated the hemodynamic effects of PTH(1-34) or PTH(2-34), while it prevented those of [Nle8,18Tyr34]PTH(3-34). These results clearly demonstrate that the first amino acid of PTH is essential for its chronotropic property whereas the first 3 amino acids of PTH are involved in its coronary vasodilatory action. Furthermore, protein kinase A. but not protein kinase C. appears to be involved in the chronotropic and coronary vasodilatory actions of PTH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:05:38