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Titolo:
P300 and LORETA: Comparison of normal subjects and schizophrenic patients
Autore:
Winterer, G; Mulert, C; Mientus, S; Gallinat, J; Schlattmann, P; Dorn, H; Herrmann, WM;
Indirizzi:
NIMH, Mol Neuroimaging Unit, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Disorders Branch, NIH, Bethesda, MD 20892 USA Free Univ Berlin, Dept Psychiat, Lab Clin Psychophysiol, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 hophysiol, D-1000 Berlin, Germany
Titolo Testata:
BRAIN TOPOGRAPHY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 299 - 313
SICI:
0896-0267(200122)13:4<299:PALCON>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY; SUPERIOR TEMPORAL GYRUS; TO-NOISE RATIO; INTRACEREBRAL POTENTIALS; AUDITORY ODDBALL; VISUAL-STIMULI; RARE TARGET; OSCILLATORY RESPONSES; ENDOGENOUS POTENTIALS;
Keywords:
P300; LORETA; schizophrenia; left hemisphere; cortical network;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Winterer, G NIMH, Mol Neuroimaging Unit, Clin Brain Disorders Branch, NIH,Bldg 10,Room 4S229A,MSC 1379, Bethesda, MD 20892 USA NIMH Bldg 10,Room 4S229A,MSC 1379 Bethesda MD USA 20892 92 USA
Citazione:
G. Winterer et al., "P300 and LORETA: Comparison of normal subjects and schizophrenic patients", BRAIN TOPOG, 13(4), 2001, pp. 299-313

Abstract

It was the aim of the present study 1) to investigate how many cortical activity maxima of scalp-recorded P300 are detected by Low Resolution Electromagentic Tomography (LORETA) when analyses are performed with high time-resolution, 2) to see if the resulting LORETA-solution is in accordance with intracortical recordings as reported by others and 3) to compare the given pattern of cortical activation maxima in the P300-timeframe between schizophrenic patients and normal controls. Current density analysis was performed in 3-D Talairach space with high time resolution i.e. in 6 ms steps. This was done during an auditory choice reaction paradigm separately for normal subjects and schizophrenic patients with subsequent group comparisons. In normal subjects, a sequence of at least seven cortical activation maxima was found between 240-420ms poststimulus: the prefrontal cortex, anterior or medial cingulum, posterior cingulum, parietal cortex, temporal lobe, prefrontal cortex, medial or anterior cingulum. Within the given limits of spatial resolution, this sequential maxima distribution largely met the expectations from reports on intracranial recordings and functional neuroimaging studies. However, localization accuracy was higher near the central midline thanat lateral aspects of the brain. Schizophrenic patients less activated their cortex in a widespread area mainly in the left hemisphere including the prefrontal cortex, posterior cingulum and the temporal lobe. From these analyses and comparsions, with intracranial recordings as reported by others, it is concluded that LORETA correctly localizes P300-related cortical activity maxima on the basis of 19 electrodes except for lateral cortical aspects which is most likely an edge-phenomenon. The data further suggest that the P300-deficit in schizophrenics involves an extended cortical network of the left hemisphere at several steps in time during the information processing stream.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:56:12