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Titolo:
Opposite regulation of body temperature by cholinergic input to the paraventricular nucleus and supraoptic nucleus in rats
Autore:
Takahashi, A; Ishimaru, H; Ikarashi, Y; Kishi, E; Maruyama, Y;
Indirizzi:
Gunma Univ, Dept Neuropsychopharmacol, Sch Med, Gunma 3718511, Japan GunmaUniv Gunma Japan 3718511 opharmacol, Sch Med, Gunma 3718511, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 909, anno: 2001,
pagine: 102 - 111
SICI:
0006-8993(20010803)909:1-2<102:OROBTB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; PREOPTIC AREA; LOCUS COERULEUS; NEUROPEPTIDE-Y; OSMOSENSITIVE NEURONS; ACETYLCHOLINE-RELEASE; EFFERENT CONNECTIONS; SYMPATHETIC OUTFLOW; HYPOTHALAMIC NUCLEI; NERVOUS-SYSTEM;
Keywords:
hypothalamic cholinergic system; body temperature; paraventricular nucleus; supraoptic nucleus; microdialysis; c-Fos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, A Tsumura & Co, Tsumura Res Inst, 3586 Yoshiwara, Ami, Ibaraki 30011, Japan Tsumura & Co 3586 Yoshiwara Ami Ibaraki Japan 30011 11, Japan
Citazione:
A. Takahashi et al., "Opposite regulation of body temperature by cholinergic input to the paraventricular nucleus and supraoptic nucleus in rats", BRAIN RES, 909(1-2), 2001, pp. 102-111

Abstract

Hypothalamic cholinergic system plays an important role in the regulation of body temperature and fluid balance. We have previously shown that cholinergic stimulation of the anterior hypothalamus and preoptic area was accompanied by a fall in body temperature, increased water intake, and increased Fos protein in the paraventricular nucleus (PVN) and supraoptic nucleus (SON). In the present study, to estimate the role played by cholinergic input to the PVN and SON in thermoregulation and water intake, we used microdialysis for cholinergic stimulation with neostigmine and analysis of the nucleus, and also investigated immunoreactivity for c-Fos protein in the brain. This stimulation increased extracellular concentration of acetylcholine in these nuclei. Stimulation of the PVN decreased body temperature and increased water intake. On the other hand, stimulation of the SON increased body temperature. Both in PVN-stimulated and SON-stimulated rats, c-Fos-like immunoreactivity (Fos-IR) was evident in the PVN, SON and certain regions including locus coeruleus (LC), area postrema and nucleus of the solitary tract (NTS). Addition of atropine to the dialysis medium attenuated the increase of Fos-IR and suppressed the cholinergic stimulation-induced responses in body temperature and water intake. These results suggest that cholinergic muscarinic mechanisms in PVN and SON play an opposite function in the regulation of body temperature. The same neuronal pathway including LC and NTS may participate in an advance both in hypothermia and in hyperthermia. (C) 2001Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 15:09:15