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Titolo:
Inhibition of prostaglandin synthesis reduces hyperthermic reactions induced by hypocretin-1/orexin A
Autore:
Monda, M; Viggiano, A; Mondola, P; De Luca, V;
Indirizzi:
Univ Naples 2, Dept Expt Med, Sect Human Physiol, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 Human Physiol, I-80138 Naples, Italy Univ Naples Federico II, Dept Neurosci, Physiol Sect, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 Sect, I-80131 Naples, Italy
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 909, anno: 2001,
pagine: 68 - 74
SICI:
0006-8993(20010803)909:1-2<68:IOPSRH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSHIVERING THERMOGENESIS; POSTERIOR HYPOTHALAMUS; ANESTHETIZED RATS; FOOD-INTAKE; HEART-RATE; OREXINS; ACTIVATION; STIMULATION; ENDOTOXIN; INJECTION;
Keywords:
autonomic nervous system; body temperature; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Monda, M Univ Naples 2, Dept Expt Med, Sect Human Physiol, Via Costantinopoli 16, I-80138 Naples, Italy Univ Naples 2 Via Costantinopoli 16 Naples Italy I-80138 , Italy
Citazione:
M. Monda et al., "Inhibition of prostaglandin synthesis reduces hyperthermic reactions induced by hypocretin-1/orexin A", BRAIN RES, 909(1-2), 2001, pp. 68-74

Abstract

This experiment tested (i) the effect of orexin A injected into a lateral cerebral ventricle on sympathetic and thermogenic activity and (ii) the involvement of prostaglandins in these phenomena. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with MATand colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before and 6 h after an injection of orexin A (1.5 nmol) into the lateral cerebral ventricle. The same variables were monitored in rats with an intraperitoneal administration of lysine acetylsalicylate, (100 mg/kg bw), an inhibitor of prostaglandins synthesis. The results show that orexin A increases the sympathetic firing rate, IBAT and colonic temperatures and heart rate. This increase is reduced by lysine acetylsalicylate. These findings suggest that orexin A affects sympathetic activity, which controls body temperature. Prostaglandins are involved in this control. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:28:19