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Titolo:
Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep
Autore:
Mackenzie, TC; Flake, AW;
Indirizzi:
Childrens Hosp Philadelphia, Childrens Inst Surg Sci, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA
Titolo Testata:
BLOOD CELLS MOLECULES AND DISEASES
fascicolo: 3, volume: 27, anno: 2001,
pagine: 601 - 604
SICI:
1079-9796(200105/06)27:3<601:HMSCPD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-UTERO TRANSPLANTATION; SEVERE COMBINED IMMUNODEFICIENCY; BONE-MARROW; ENGRAFTMENT; EXPRESSION; COTRANSPLANTATION; PROGENITORS; INUTERO; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Flake, AW Childrens Hosp Philadelphia, Childrens Inst Surg Sci, 34th St & Civ Ctr Blvd, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia 34th St & Civ Ctr Blvd Philadelphia PA USA 19104
Citazione:
T.C. Mackenzie e A.W. Flake, "Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep", BL CELL M D, 27(3), 2001, pp. 601-604

Abstract

Prenatal transplantation of stem cells is an exciting frontier for the treatment of many congenital diseases. The fetus may be an ideal recipient forstem cells, as it is immunologically immature and has rapidly proliferating cellular compartments that may support the engraftment of transplanted cells. Mesenchymal stem cells (MSC), given their ability to differentiate into multiple cell types, could potentially be used to treat diseases such as osteogenesis imperfecta, muscular dystrophy, and other mesenchymal disorders that can be diagnosed in utero. We have shown, using a human-sheep in utero xenotransplantation model, that human MSC have the ability to engraft, undergo site-specific differentiation into multiple cell types, and survive for more than 1 year in fetal lamb recipients. In addition, in this model MSC-derived cells appear to be present in increased numbers in wounded or regenerating tissues. This observation warrants further studies of the biology of MSCs following systemic or site-directed transplantation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:56:16