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Titolo:
Development of C-20 modified betulinic acid derivatives as antitumor agents
Autore:
Kim, JY; Koo, HM; Kim, DSHL;
Indirizzi:
Univ Illinois, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 Pharmaceut Sci, Chicago, IL 60612 USA Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 & Pharmacognosy, Chicago, IL 60612 USA Van Andel Res Inst, Grand Rapids, MI 49503 USA Van Andel Res Inst Grand Rapids MI USA 49503 , Grand Rapids, MI 49503 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 17, volume: 11, anno: 2001,
pagine: 2405 - 2408
SICI:
0960-894X(20010903)11:17<2405:DOCMBA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-AIDS AGENTS; HUMAN-MELANOMA; TRITERPENE DERIVATIVES; MALIGNANT-MELANOMA; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, DSHL Univ Illinois, Program Collaborat Res Pharmaceut Sci, 833 S WoodSt, Chicago, IL 60612 USA Univ Illinois 833 S Wood St Chicago IL USA 60612o, IL 60612 USA
Citazione:
J.Y. Kim et al., "Development of C-20 modified betulinic acid derivatives as antitumor agents", BIOORG MED, 11(17), 2001, pp. 2405-2408

Abstract

Chemical modifications were performed on C-20 position of betulinic acid for a structure-activity relationship study. The evaluation of the compoundsusing human colon carcinoma HCT-116, human prostate adenocarcinoma PC3, and human melanoma cell lines M14-MEL, SK-MEL-2, and UACC-257 did not show any selective cytotoxicity towards melanoma cells. The results from both MTT reduction assay and SRB staining assay were comparable that no remarkable differences in cytotoxicity profile of the compounds were noticed. The C-20 position was found to be sensitive to the size and the electron density of the substituents in retaining the cytotoxicity of betulinic acid and was found to be undesirable position to derivatize. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:51:35