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Titolo:
Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor
Autore:
Kordik, CP; Luo, C; Zanoni, BC; Dax, SL; McNally, JJ; Lovenberg, TW; Wilson, SJ; Reitz, AB;
Indirizzi:
RW Johnson Pharmaceut Res Inst, Drug Discovery Div, Spring House, PA 19477USA RW Johnson Pharmaceut Res Inst Spring House PA USA 19477 use, PA 19477USA RW Johnson Pharmaceut Res Inst, Drug Discovery Div, San Diego, CA 92121 USA RW Johnson Pharmaceut Res Inst San Diego CA USA 92121 Diego, CA 92121 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 17, volume: 11, anno: 2001,
pagine: 2283 - 2286
SICI:
0960-894X(20010903)11:17<2283:AWHAFT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE-YY; FOOD-INTAKE; ANTAGONISTS; EXPRESSION; SUBTYPES; CLONING; POTENT; Y-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kordik, CP RW Johnson Pharmaceut Res Inst, Drug Discovery Div, Welsh & McKean Rd, Spring House, PA 19477 USA RW Johnson Pharmaceut Res Inst Welsh & McKean Rd Spring House PA USA 19477
Citazione:
C.P. Kordik et al., "Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor", BIOORG MED, 11(17), 2001, pp. 2283-2286

Abstract

1,3-Disubstituted-5-aminopyrazoles were prepared based on a lead compound found through high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. The target compounds were prepared by cyclization of alpha -cyanoketones with appropriate hydrazines, followed by reduction and coupling to various sulfonamido-carboxylic acids. Several of these arylpyrazoles (e.g., 19 and 45) displayed high affinity for the human NPY Y5 receptor (< 20 nM IC(50)s). (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:59:55