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Titolo:
Modulation of immunostimulatory activity of CpG oligonucleotides by site-specific deletion of nucleobases
Autore:
Yu, D; Kandimalla, ER; Zhao, QY; Cong, YP; Agrawal, S;
Indirizzi:
Hybridon Inc, Cambridge, MA 02139 USA Hybridon Inc Cambridge MA USA 02139Hybridon Inc, Cambridge, MA 02139 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 17, volume: 11, anno: 2001,
pagine: 2263 - 2267
SICI:
0960-894X(20010903)11:17<2263:MOIAOC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE; BACTERIAL-DNA; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Agrawal, S Hybridon Inc, 345 Vassar St, Cambridge, MA 02139 USA Hybridon Inc 345 Vassar St Cambridge MA USA 02139 MA 02139 USA
Citazione:
D. Yu et al., "Modulation of immunostimulatory activity of CpG oligonucleotides by site-specific deletion of nucleobases", BIOORG MED, 11(17), 2001, pp. 2263-2267

Abstract

The effect of nucleobase deletion in the 3 '- or the 5 ' -flanking sequence to a CpG-motif on immunostimulatory activity of CpG-containing oligonucleotides was examined by cell proliferation, secretion of IL-12 and IL-6 in mouse spleen cell cultures, and by spleen enlargement in mice. Deletion of one or two nucleobases in the 3 ' -flanking sequence to a CpG-motif at certain positions did not affect immunostimulatory activity, while similar deletions in the 5 ' -flanking sequence increased immunostimulatory activity compared with the parent oligo. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:34:28