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Titolo:
Thalamic activation during an attention-to-prepulse startle modification paradigm: A functional MRI study
Autore:
Hazlett, EA; Buchsbaum, MS; Tang, CY; Fleischman, MB; Wei, TC; Byne, W; Haznedar, MM;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA CUNY Mt SinaiSch Med New York NY USA 10029 chiat, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Radiol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 adiol, New York, NY 10029 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 50, anno: 2001,
pagine: 281 - 291
SICI:
0006-3223(20010815)50:4<281:TADAAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; ACOUSTIC STARTLE; EYEBLINK MODIFICATION; REFLEX MODIFICATION; GLUCOSE-METABOLISM; SCHIZOPHRENIA; PET; INHIBITION; DOPAMINE; RAT;
Keywords:
fMRI; startle; prepulse inhibition; attention; thalamus; medial dorsal nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Hazlett, EA CUNY Mt Sinai Sch Med, Dept Psychiat, Box 1505, New York, NY 10029 USA CUNY Mt Sinai Sch Med Box 1505 New York NY USA 10029 10029 USA
Citazione:
E.A. Hazlett et al., "Thalamic activation during an attention-to-prepulse startle modification paradigm: A functional MRI study", BIOL PSYCHI, 50(4), 2001, pp. 281-291

Abstract

Background: Prepulse inhibition (PPI) of the startle reflex reflects earlystages of information processing and is modulated by selective attention. Animal models indicate medial frontal-thalamic circuitry is important in PPI modulation. We report data from the first functional magnetic resonance imaging (fMRI) study examining whether attending to or ignoring a prepulse differentially activates brain areas within this circuitry. Methods: Ten healthy subjects received structural and functional MRL During fMRI acquisition, subjects heard intermixed attended and ignored tones serving as prepulses to the startle stimulus. Regions of interest were tracedon structural MR1 and coregistered to fMRI images. Results: Greater amplitude fMRI blood-oxygen-level-dependent response to attended than ignored PPI conditions occurred in the right thalamus, and bilaterally in the anterior and mediodorsal thalamic nuclei, whereas the startle-alone condition showed deactivation. In transitional medial cortex (Brodmann Area 32), which is involved in affective processing of noxious stimuli, the startle-alone condition elicited the greatest response, the attended-PPI condition showed the smallest response, and the ignored-PP1 condition was intermediate. Conclusions: These findings extend animal models to humans by indicating thalamic involvement in the modulation of PPI. Further fMRI investigations may elucidate other kev structures in the circuitry underlying normal and disordered modulation of PPL (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:34:19