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Titolo:
Abnormal salivary cortisol levels in social phobic patients in response toacute psychological but not physical stress
Autore:
Furlan, PM; DeMartinis, N; Schweizer, E; Rickels, K; Lucki, I;
Indirizzi:
Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Psychol, Philadelphia, PA 19104 USA Univ Penn, Behav Psychopharmacol Lab, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 macol Lab, Philadelphia, PA 19104 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 50, anno: 2001,
pagine: 254 - 259
SICI:
0006-3223(20010815)50:4<254:ASCLIS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY FREE CORTISOL; PANIC DISORDER; ANXIETY;
Keywords:
salivary cortisol; social phobia; acute stress; HPA axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Lucki, I Univ Penn, Sch Med, Dept Psychiat, 415 Curie Blvd,538A Clin Res Bldg, Philadelphia, PA 19104 USA Univ Penn 415 Curie Blvd,538A Clin Res BldgPhiladelphia PA USA 19104
Citazione:
P.M. Furlan et al., "Abnormal salivary cortisol levels in social phobic patients in response toacute psychological but not physical stress", BIOL PSYCHI, 50(4), 2001, pp. 254-259

Abstract

Background: Little is known about the hypothalamic-pituitary adrenal axis response to acute stressfid behavioral challenges in patients with social phobia. Methods: Eighteen patients with social phobia and 17 normal volunteers participated in two behavioral stressors: a speech task and physical exercise. Results: Normal volunteers (n = 14) demonstrated a significant 50% increase in salivary cortisol levels to the speech task. Three nonresponding normal volunteers demonstrated a 17% decrease. In contrast, patients with socialphobia demonstrated dichotomous changes. Seven social phobia patients demonstrated a significantly higher 90% increase in salivary cortisol to the speech task, whereas the remaining patients (n = 11) were nonresponders demonstrating a 32% decrease in cortisol. Both patient groups were significantlymore anxious than the normal volunteers. In contrast to the response to a speech task, social phobics showed a cortisol response to physical exerciseof similar magnitude as normal volunteers. Conclusions: The results indicated dichotomies in magnitude and bt distribution of the cortisol response to a speech task between social phobia patients and normal volunteers. Social phobia patients responded differently than normal volunteers to a stressor associated with social evaluation but notto physical exercise. These results suggest adaptation of distinct biological processes spec ftc to different stressfid conditions in social phobia. (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:50:49