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Titolo:
Genetic predisposition and the development of Posttraumatic stress disorder in an animal model
Autore:
King, JA; Abend, S; Edwards, E;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Psychiat, Med Ctr, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 ed Ctr, Worcester, MA 01655 USA Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 rmaceut Sci, Baltimore, MD 21201 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 50, anno: 2001,
pagine: 231 - 237
SICI:
0006-3223(20010815)50:4<231:GPATDO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD SEXUAL ABUSE; COMBAT VETERANS; PHYSICAL ABUSE; WOMEN; RATS; ANALGESIA; SYMPTOMS; MEMORY; TRAUMA; HIPPOCAMPUS;
Keywords:
PTSD; learned helplessness; footshock stress; animal model; corticosterone; analgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: King, JA Univ Massachusetts, Sch Med, Dept Psychiat, Med Ctr, 55 Lake Ave N, Worcester, MA 01655 USA Univ Massachusetts 55 Lake Ave N Worcester MA USA 01655 01655 USA
Citazione:
J.A. King et al., "Genetic predisposition and the development of Posttraumatic stress disorder in an animal model", BIOL PSYCHI, 50(4), 2001, pp. 231-237

Abstract

Background: Exposure to extremely stressful events can lead to Posttraumatic stress disorder (PTSD). Due to the complexity of PTSD, animal models have been designed and advanced to address the role of psychosocial stressors in the etiology; however, the apparent role of genetics in susceptibility to PTSD-like behaviors in animals remains unexplored. Methods: An animal model of congenital learned helpless (cLH) behavior hasbeen used to study the effects of genetic disposition as a risk factor forthe development of PTSD-like behaviors. Animals were monitored for changesin pain tolerance, spatial memory and hypothalamic-pituitary-adrenal functioning after re-exposure to intermittent stress in the presence and absenceof situational cues. Results: Exposure to stress resulted in an increase in pain tolerance in the cLH animals. In the spatial memory test 80% of the cLH animals manifested a decrease in performance after exposure to stress. These animals also had a blunted poststress corticosterone response. Conclusions: The genetic learned helpless animal model exhibited physiologic symptoms of analgesia, cognitive deficits and hyporesponsivity of the hypothalainic-pituitan-adrenal axis similar to those observed in human Subjects with PTSD. It is proposed that the cLH model may be a valuable tool for exploring the role of genetic predisposition in the etiology of PTSD. (C) 2001 Society of Biological Psychiatry.

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Documento generato il 01/04/20 alle ore 02:14:42