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Titolo:
Functional genomics in HIV-1 virus replication: Protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation
Autore:
Tasara, T; Hottiger, MO; Hubscher, U;
Indirizzi:
Univ Zurich, Inst Vet Biochem, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 chem, CH-8057 Zurich, Switzerland
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 7, volume: 382, anno: 2001,
pagine: 993 - 999
SICI:
1431-6730(200107)382:7<993:FGIHVR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-1 REVERSE-TRANSCRIPTASE; BINDING-PROTEIN; TOPOISOMERASE-I; NUCLEAR IMPORT; VPR INTERACTS; TRANSPORT; TAT; PATHWAYS; CYCLE; P300;
Keywords:
HIV-1 gene expression; integration; preintegration complex (PIC); reverse transcription;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Hubscher, U Univ Zurich, Inst Vet Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich Winterthurerstr 190 Zurich Switzerland CH-8057 nd
Citazione:
T. Tasara et al., "Functional genomics in HIV-1 virus replication: Protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation", BIOL CHEM, 382(7), 2001, pp. 993-999

Abstract

Identification and characterization of protein-protein interactions between the host cell and parasites both enhance our understanding of basic cell biology and provide insights into central processes of parasite life cycles. Research on HIV-1 has broadened our knowledge of the various molecular events involved. However, our understanding of how this virus interacts with the host cell at the level of protein-protein interaction is still limited. Through these interactions the virus is able to recruit certain cellular metabolic pathways for its replication. Here we summarize our current knowledge of protein-protein interactions between HIV-1 and host cell factors during viral replication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:01:07