Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Elongated dermatan sulphate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps
Autore:
Kuwaba, K; Kobayashi, M; Nomura, Y; Irie, S; Koyama, Y;
Indirizzi:
Nippi Inc, Nippi Res Inst Biomatrix, Adachi Ku, Tokyo 1208601, Japan NippiInc Tokyo Japan 1208601 Biomatrix, Adachi Ku, Tokyo 1208601, Japan Nagoya Univ, Grad Sch Med, Dept Funct Anat, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Tokyo Univ Agr & Technol, Fac Agr, Fuchu, Tokyo 1838509, Japan Tokyo Univ Agr & Technol Fuchu Tokyo Japan 1838509 , Tokyo 1838509, Japan
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 358, anno: 2001,
parte:, 1
pagine: 157 - 163
SICI:
0264-6021(20010815)358:<157:EDSIPH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN SULFATE BIOSYNTHESIS; GROWTH-FACTOR-BETA; EXTRACELLULAR-MATRIX; CONNECTIVE TISSUES; HYPERTROPHIC SCAR; HIGH-AFFINITY; PROTEOGLYCANS; DECORIN; FIBRILLOGENESIS; ORGANIZATION;
Keywords:
Cupromeronic Blue; decorin; hapten;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Koyama, Y Nippi Inc, Nippi Res Inst Biomatrix, Adachi Ku, 1-1 Senju Midoricho, Tokyo1208601, Japan Nippi Inc 1-1 Senju Midoricho Tokyo Japan 1208601208601, Japan
Citazione:
K. Kuwaba et al., "Elongated dermatan sulphate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps", BIOCHEM J, 358, 2001, pp. 157-163

Abstract

It has been reported that the disaccharide composition of dermatan sulphate shows transient changes after epicutaneous application of the hapten 2,4-dinitrofluorobenzene to mouse skin, and that these changes are most conspicuous in healing skin on day 15 after chemical insult [Kuwaba, Nomura, Irie and Koyama (1999) J. Dermatol. Sci. 19, 23 30]. In the present study it wasfound that the molecular size of dermatan sulphate was increased on day 15after hapten application. The molecular size of decorin increased in healing skin, whereas the size of dermatan-sulphate-depleted core protein did not increase. The length and localization of decorin dermatan sulphate were investigated by electron microscopy. Dermatan sulphate filaments oriented orthogonally to collagen fibrils were longer in healing skin than in control skin. In control skin, dermatan sulphate filaments were found among tightlypacked collagen fibrils. In contrast, the interfibrillar gaps between eachcollagen fibril were enlarged in healing skin; elongated dermatan sulphatefilaments extended from the surface of collagen fibrils across the enlarged gap. These results suggest that the increase in molecular size of decorindermatan sulphate is important in organizing collagen fibrils separated byenlarged interfibrillar gaps in healing skin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:53:23