Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACE genotype and endothelium-dependent vasodilation of conduit arteries and forearm microcirculation in humans
Autore:
Arcaro, G; Solini, A; Monauni, T; Cretti, A; Brunato, B; Lechi, A; Fellin, R; Caputo, M; Cocco, C; Bonora, E; Muggeo, M; Bonadonna, RC;
Indirizzi:
Univ Verona, Sch Med, Dept Biomed & Surg Sci, Div Endocrinol & Metab Dis, Verona, Italy Univ Verona Verona Italy Sci, Div Endocrinol & Metab Dis, Verona, Italy Univ Verona, Sch Med, Dept Biomed & Surg Sci, Div Internal Med, Verona, Italy Univ Verona Verona Italy ed & Surg Sci, Div Internal Med, Verona, Italy Verona City Hosp, Lab Med Unit, Verona, Italy Verona City Hosp Verona Italy na City Hosp, Lab Med Unit, Verona, Italy Univ Ferrara, Sch Med, Dept Internal Med, Div Gen Med, Ferrara, Italy UnivFerrara Ferrara Italy pt Internal Med, Div Gen Med, Ferrara, Italy
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 8, volume: 21, anno: 2001,
pagine: 1313 - 1319
SICI:
1079-5642(200108)21:8<1313:AGAEVO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; GENE INSERTION/DELETION POLYMORPHISM; DELETION POLYMORPHISM; CARDIOVASCULAR-DISEASE; DIABETIC-PATIENTS; SKELETAL-MUSCLE; MICROALBUMINURIA; HEART; ATHEROSCLEROSIS; HYPERTENSION;
Keywords:
ACE/angiotensin receptors; cardiovascular disease; endothelium/vascular type/nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Bonadonna, RC Osped Civile, Div Endocrinol, Piazzale Stefani 1, I-37126 Verona, Italy Osped Civile Piazzale Stefani 1 Verona Italy I-37126 Italy
Citazione:
G. Arcaro et al., "ACE genotype and endothelium-dependent vasodilation of conduit arteries and forearm microcirculation in humans", ART THROM V, 21(8), 2001, pp. 1313-1319

Abstract

The ACE gene is a candidate gene for cardiovascular disease. Endothelial dysfunction is considered an intermediate phenotype in the pathogenesis of hypertension and atherosclerosis. We evaluated the role of ACE gene polymorphism in endothelial function of young healthy humans. We assessed ACE genotype (deletion [D]/insertion [I] polymorphism) in 92 young healthy individuals. In 88 of them, endothelium-dependent (flow-mediated) vasodilation and endothelium-independent (nitroglycerin-induced) vasodilation were measured in the common femoral artery and in the brachial (n=84) artery by echo Doppler technique. In 35 subjects, we also applied the forearm perfusion technique to quantify the responses of the forearm vascular bed to 3 increasing doses of 2 endothelium-dependent vasodilators (acetylcholine and bradykinin) and 1 endothelium-independent vasodilator (sodium nitroprusside). The D allele of the ACE gene was associated with a significant blunting (Delta approximate to 26%) of endothelium-dependent vasodilation in the femoral artery (P=0.02) but not in the brachial artery (P=0.55) or in the forearm microcirculation (P=0.70 to 0.80). Endothelium-independent vasodilation was unaffected by the ACE genotype. In young healthy humans, the D allele of the ACE gene is associated with selective endothelial dysfunction of the femoral artery. It remains to be determined whether this association discloses a causal role in vascular, particularly peripheral artery, disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 11:27:50