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Titolo:
Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats
Autore:
Nan, JX; Park, EJ; Yang, BK; Song, CH; Ko, GN; Sohn, DH;
Indirizzi:
Wonkwang Univ, Coll Pharm, Med Resources Res Ctr, Iksan 570749, Cheonbuk, South Korea Wonkwang Univ Iksan Cheonbuk South Korea 570749 49, Cheonbuk, South Korea Taegu Univ, Dept Biotechnol, Kyungsan 712714, Kyungbuk, South Korea Taegu Univ Kyungsan Kyungbuk South Korea 712714 14, Kyungbuk, South Korea Yanbian Univ, Coll Pharm, Yanji 133000, Jilin, Peoples R China Yanbian Univ Yanji Jilin Peoples R China 133000 0, Jilin, Peoples R China
Titolo Testata:
ARCHIVES OF PHARMACAL RESEARCH
fascicolo: 4, volume: 24, anno: 2001,
pagine: 327 - 332
SICI:
0253-6269(200108)24:4<327:AEOEBF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLYL 4-HYDROXYLASE; CARBON-TETRACHLORIDE; GANODERMA-LUCIDUM; INHIBITION; COLLAGEN; EXTRACT; INJURY;
Keywords:
bile duct ligation and scission; Cordyceps militaris; liver fibrosis; lipid peroxidation; alpha-smooth muscle like actin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sohn, DH Wonkwang Univ, Coll Pharm, Med Resources Res Ctr, Iksan 570749, Cheonbuk, South Korea Wonkwang Univ Iksan Cheonbuk South Korea 570749 buk, South Korea
Citazione:
J.X. Nan et al., "Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats", ARCH PH RES, 24(4), 2001, pp. 327-332

Abstract

The antifibrotic effects of hot water extract (WEC), intracellular biopolymer (IPC) and extracellular biopolymers (EPC) from mycelial liquid culture of Cordyceps militaris on liver fibrosis were studied. Liver fibrosis was induced by a bile duct ligation and scission (BDL/S) operation, duration of 4 weeks in rats. In BDL/S rats, the levels of aspartate transaminase (AST),alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin inserum and hydroxyproline content in liver were dramatically increased. TheWEC or IPC treatment (30 mg/kg/day for 4 weeks, p.o.) in BDL/S rats reduced the serum AST, ALT and ALP levels significantly (p < 0.01). The EPC treatment (30 mg/kg/day for 4 weeks, p.o.) reduced the serum ALT, AST and ALP levels significantly (p < 0.01). Malondialdehyde contents in liver treated with WEC, IPC or EPC were significantly reduced (p < 0.05). But Liver hydroxyproline content was decreased only in EPC treated BDL/S rats to 55% that ofBDL/S control rats (p < 0.01). The morphological characteristics and expression of alpha smooth muscle like actin in fibrotic liver, which appeared in BDL/S control group were improved in EPC treated fibrotic liver. These results indicate that EPC (30 mg/kg/day for 4 weeks, p.o.) has an antifibrotic effect on fibrotic rats induced by BDL/S.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:41:14