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Titolo:
Immunohistochemical detection of lipid peroxidation products, protein-bound acrolein and 4-hydroxynonenal protein adducts, in actinic elastosis of photodamaged skin
Autore:
Tanaka, N; Tajima, S; Ishibashi, A; Uchida, K; Shigematsu, T;
Indirizzi:
Natl Def Med Coll, Dept Dermatol, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan Nagoya Univ, Grad Sch Bioagr Sci, Lab Food & Biodynam, Aichi 4648601, Japan Nagoya Univ Aichi Japan 4648601 ab Food & Biodynam, Aichi 4648601, Japan Pias Cosmet Inst, Kita Ku, Osaka 5310072, Japan Pias Cosmet Inst Osaka Japan 5310072 Inst, Kita Ku, Osaka 5310072, Japan
Titolo Testata:
ARCHIVES OF DERMATOLOGICAL RESEARCH
fascicolo: 7, volume: 293, anno: 2001,
pagine: 363 - 367
SICI:
0340-3696(200107)293:7<363:IDOLPP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; SUN-DAMAGED SKIN; END-PRODUCT; EXPRESSION; ELASTIN; FIBROBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, N Natl Def Med Coll, Dept Dermatol, 3-2 Namiki, Tokorozawa, Saitama 3598513,Japan Natl Def Med Coll 3-2 Namiki Tokorozawa Saitama Japan 3598513 an
Citazione:
N. Tanaka et al., "Immunohistochemical detection of lipid peroxidation products, protein-bound acrolein and 4-hydroxynonenal protein adducts, in actinic elastosis of photodamaged skin", ARCH DERM R, 293(7), 2001, pp. 363-367

Abstract

Acrolein and 4-hydroxy-2-nonenal (FINE) are both byproducts of a lipid peroxidation reaction. Actinic elastosis in photodamaged skin of aged individuals is characterized by the accumulation of fragmented elastic fibers in the sun-exposed areas. To study whether a lipid peroxidation reaction is involved in the accumulation of altered elastic fibers in actinic elastosis, skin specimens obtained from sun-damaged areas were immunohistochemically examined using the antibodies against acrolein and HNE. Both antibodies were found to react with the accumulations of elastic material. Double immunofluorescence labeling demonstrated that acrolein/elastin and HNE/elastin were colocalized in the actinic elastosis. Western blot analysis showed that the polypeptide with a molecular weight of 62 kDa reacted with anti-acrolein, anti-HNE and anti-elastin antibodies. The results suggest that acrolein and HNE may be associated with actinic elastosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:07:16