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Titolo:
Intrinsic expression of drug resistance-associated factors in meningiomas
Autore:
Tews, DS; Fleissner, C; Tiziani, B; Gaumann, AKA;
Indirizzi:
Univ Mainz, Div Neuropathol, Med Ctr, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 pathol, Med Ctr, D-55101 Mainz, Germany Univ Mainz, Dept Pathol, Med Ctr, D-6500 Mainz, Germany Univ Mainz MainzGermany D-6500 t Pathol, Med Ctr, D-6500 Mainz, Germany
Titolo Testata:
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
fascicolo: 3, volume: 9, anno: 2001,
pagine: 242 - 249
SICI:
1062-3345(200109)9:3<242:IEODRF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY ENDOTHELIAL-CELLS; HUMAN GLIOMA-CELLS; HUMAN BRAIN-TUMORS; MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; MALIGNANT MENINGIOMAS; RECURRENT MENINGIOMAS; GLIOBLASTOMA CELLS; ANTICANCER DRUGS; PROTEIN MRP;
Keywords:
chemotherapy; drug resistance; meningiomas; recurrence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Tews, DS Univ Mainz, Div Neuropathol, Med Ctr, Langenbeckstr 1, D-55101 Mainz, Germany Univ Mainz Langenbeckstr 1 Mainz Germany D-55101 Mainz, Germany
Citazione:
D.S. Tews et al., "Intrinsic expression of drug resistance-associated factors in meningiomas", APPL IMMUNO, 9(3), 2001, pp. 242-249

Abstract

Meningiomas, commonly benign tumors, rarely display aggressive behavior byrecurrences and invasion. In addition to surgery, irradiation is beneficial for recurrent. atypical. and malignant meningiomas. The role of chemotherapy. however, remains controversial, although there is evidence that meningiomas respond well to adjuvant chemotherapy. A major obstacle in chemotherapy remains drug resistance with reduced cellular drug accumulation through membrane efflux pumps, drug detoxification. and alterations in drug target specificity. In 84 classic. atypical, and malignant meningiomas, the immunohistochemical expression profile of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), metallothionein, and topoisomerase II alpha were studied. All types of meningiomas showed constant expression of P-gp, LRP, MRP, and topoisomerase II alpha: metallothionein was found in 67% of the tumors. especially in atypical and malignant meningiomas. Furthermore. metallothionein, P-gp, LRP and topoisomerase II alpha were strongly expressed by normal and neoplastic vessels, which may confer to impaired penetration of therapeutic agents through the blood-brain and blood-tumor barrier. Neither recurrent nor pre, iously irradiated meningiomas revealed any significant difference to primary tumors. These intrinsic drug resistances indicate that successful chemotherapy may require additional inhibition of these factors to be a promising approach inthe management of meningiomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:14:48