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Titolo:
Stability and compatibility of ceftazidime administered by continuous infusion to intensive care patients
Autore:
Servais, H; Tulkens, PM;
Indirizzi:
Univ Catholique Louvain, Unite Pharmacol Cellulaire & Mol, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 9, volume: 45, anno: 2001,
pagine: 2643 - 2647
SICI:
0066-4804(200109)45:9<2643:SACOCA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-LACTAM ANTIBIOTICS; PENICILLIN-G; PHYSICOCHEMICAL PROPERTIES; CEFAZOLIN SODIUM; PLASTIC SYRINGES; PUMP RESERVOIRS; DEGRADATION; FLUCONAZOLE; PHARMACOKINETICS; PHARMACODYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Servais, H Univ Catholique Louvain, Unite Pharmacol Cellulaire & Mol, 73-70 Ave E Mounier 73, B-1200 Brussels, Belgium Univ Catholique Louvain 73-70 Ave E Mounier 73 Brussels Belgium B-1200
Citazione:
H. Servais e P.M. Tulkens, "Stability and compatibility of ceftazidime administered by continuous infusion to intensive care patients", ANTIM AG CH, 45(9), 2001, pp. 2643-2647

Abstract

The stability and compatibility of ceftazidime have been examined in the context of its potential use in concentrated solutions for continuous infusion in patients suffering from severe nosocomial pneumonia and receiving other intravenous medications by the same route. Ceftazidime stability in 4 to12% solutions was found satisfactory (< 10% degradation) for 24 h if kept at a temperature of 25 degreesC (77 degreesF) maximum. Studies mimicking the simultaneous administration of ceftazidime and other drugs as done in clinics showed physical incompatibilities with vancomycin, nicardipine, midazolam, and propofol and a chemical incompatibility with N-acetylcystein. Concentrated solutions (50 mg/ml) of erythromycin or clarithromycin caused the appearance of a precipitate, whereas gentamicin, tobramycin, amikacin, isepamicin, fluconazole, ketamine, sufentanil, valproic acid, furosemide, uradipil, and a standard amino acid solution were physically and chemically compatible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:19:36