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Titolo:
Drug interactions with clinafloxacin
Autore:
Randinitis, EJ; Alvey, CW; Koup, JR; Rausch, G; Abel, R; Bron, NJ; Hounslow, NJ; Vassos, AB; Sedman, AJ;
Indirizzi:
Pfizer Global Res & Dev, Clin Pharmacokinet & Pharmacodynam Dept, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 t, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev, Dept Expt Med, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 d, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev, Nonclin Biostat Dept, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 t, Ann Arbor, MI 48105 USA
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 9, volume: 45, anno: 2001,
pagine: 2543 - 2552
SICI:
0066-4804(200109)45:9<2543:DIWC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIPROFLOXACIN-PHENYTOIN INTERACTION; WARFARIN; PHARMACOKINETICS; FLUOROQUINOLONES; QUINOLONE; ANTICOAGULATION; TROVAFLOXACIN; THEOPHYLLINE; METABOLISM; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Randinitis, EJ Pfizer Global Res & Dev, Clin Pharmacokinet & PharmacodynamDept, 2800 Plymouth Rd, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev 2800 Plymouth Rd Ann Arbor MI USA 48105
Citazione:
E.J. Randinitis et al., "Drug interactions with clinafloxacin", ANTIM AG CH, 45(9), 2001, pp. 2543-2552

Abstract

Many fluoroquinolone antibiotics are inhibitors of cytochrome P450 enzyme systems and may produce potentially important drug interactions when administered with other drugs. Studies were conducted to determine the effect of clinafloxacin on the pharmacokinetics of theophylline, caffeine, warfarin, and phenytoin, as well as the effect of phenytoin on the pharmacokinetics of clinafloxacin. Concomitant administration of 200 or 400 mg of clinafloxacin reduces mean theophylline clearance by approximately 50 and 70%, respectively, and reduces mean caffeine clearance by 84%. (R)-Warfarin concentrations in plasma during clinafloxacin administration are 32% higher and (S)-warfarin concentrations do not change during clinafloxacin treatment. An observed late pharmacodynamic effect was most likely due to gut flora changes. Phenytoin has no effect on clinafloxacin pharmacokinetics, while phenytoin clearance is 15% lower during clinafloxacin administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:57:51