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Titolo:
Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors
Autore:
Young, HE; Steele, TA; Bray, RA; Hudson, J; Floyd, JA; Hawkins, K; Thomas, K; Austin, T; Edwards, C; Cuzzourt, J; Duenzl, M; Lucas, PA; Black, AC;
Indirizzi:
Mercer Univ, Sch Med, Div Basic Med Sci, Macon, GA 31207 USA Mercer Univ Macon GA USA 31207 ed, Div Basic Med Sci, Macon, GA 31207 USA Mercer Univ, Sch Med, Dept Pediat, Macon, GA 31207 USA Mercer Univ Macon GA USA 31207 Sch Med, Dept Pediat, Macon, GA 31207 USA Des Moines Univ, Osteopath Med Ctr, Dept Microbiol, Des Moines, IA USA DesMoines Univ Des Moines IA USA tr, Dept Microbiol, Des Moines, IA USA Emory Univ Hosp, Dept Pathol, Dept Pathol & Lab Med, Atlanta, GA 30322 USAEmory Univ Hosp Atlanta GA USA 30322 hol & Lab Med, Atlanta, GA 30322 USA Mercer Univ, Sch Med, Dept Internal Med, Macon, GA 31207 USA Mercer Univ Macon GA USA 31207 ed, Dept Internal Med, Macon, GA 31207 USA New York Med Coll, Dept Orthoped Surg, Valhalla, NY 10595 USA New York MedColl Valhalla NY USA 10595 oped Surg, Valhalla, NY 10595 USA Mercer Univ, Sch Med, Dept Obstet & Gynecol, Macon, GA 31207 USA Mercer Univ Macon GA USA 31207 Dept Obstet & Gynecol, Macon, GA 31207 USA
Titolo Testata:
ANATOMICAL RECORD
fascicolo: 1, volume: 264, anno: 2001,
pagine: 51 - 62
SICI:
0003-276X(20010901)264:1<51:HRPMSC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL PROGENITOR CELLS; MARROW STROMAL CELLS; BONE-MARROW; CD34(+) CELLS; HEMATOPOIETIC STEM; MONOCLONAL-ANTIBODY; IN-VITRO; LINE QCE-6; EXPRESSION; DIFFERENTIATION;
Keywords:
human stem cells; reserve stem cells; fetal; adult; geriatric connective tissues;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Young, HE Mercer Univ, Sch Med, Div Basic Med Sci, 1550 Coll St, Macon, GA31207 USA Mercer Univ 1550 Coll St Macon GA USA 31207 Macon, GA 31207 USA
Citazione:
H.E. Young et al., "Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors", ANAT REC, 264(1), 2001, pp. 51-62

Abstract

This study details the profile of 13 cell surface cluster differentiation markers on human reserve stem cells derived fi-om connective tissues. Stem cells were isolated from the connective tissues of dermis and skeletal muscle derived from fetal, mature, and geriatric humans. An insulin/dexamethasone phenotypic bioassay was used to determine the identity of the stem cellsfrom each population. All populations contained lineage-committed myogenic, adipogenic, chondrogenic, and osteogenic progenitor stem cells as well aslineage-uncommitted pluripotent stem cells capable of forming muscle, adipocytes, cartilage, bone, fibroblasts, and endothelial cells. Flow cytometric analysis of adult stem cell populations revealed positive staining for CD34 and CD90 and negative staining for CD3, CD4, CD8, CD11c, CD33, CD36, CD38, CD45, CD117, Glycophorin-A, and HLA DR-II. Anat Rec 264:51-62,2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:56:22