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Titolo:
Effects of ventilation with different positive end-expiratory pressures oncytokine expression in the preterm lamb lung
Autore:
Naik, AS; Kallapur, SG; Bachurski, CJ; Jobe, AH; Michna, J; Kramer, BW; Ikegami, M;
Indirizzi:
Childrens Hosp, Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA ChildrensHosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 164, anno: 2001,
pagine: 494 - 498
SICI:
1073-449X(20010801)164:3<494:EOVWDP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; NECROSIS-FACTOR-ALPHA; MECHANICAL VENTILATION; PREMATURE-INFANTS; SURFACTANT; INJURY; DISEASE; BIRTH; DELIVERY; MARKERS;
Keywords:
inflammation; lung injury; bronchopulmonary dysplasia; respiratory distress syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ikegami, M Childrens Hosp, Med Ctr, Div Pulm Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp 3333 Burnet Ave Cincinnati OH USA 45229 5229 USA
Citazione:
A.S. Naik et al., "Effects of ventilation with different positive end-expiratory pressures oncytokine expression in the preterm lamb lung", AM J R CRIT, 164(3), 2001, pp. 494-498

Abstract

Ventilator-induced lung injury increases proinflammatory cytokines in the adult lung. We asked if positive end-expiratory pressure (PEEP) affects proinflammatory cytokine mRNA expression in the preterm lung. Preterm lambs at129 +/- 3 d gestation were treated with 100 mg/kg recombinant human surfactant protein-C surfactant and ventilated for 2 or 7 h with 0, 4, or 7 cm H2O of PEEP. Unventilated fetal lambs were used as controls. Within 2 h of ventilation, alveolar total protein and activated neutrophils were increased and expression of mRNAs for the proinflammatory cytokines interleukin (IL)-1 beta, IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) was increased in lung tissue of all ventilated animals relative to unventilated controls. Alveolar protein and neutrophils were higher for 0 and 7 PEEP animals than 4 PEEP animals. IL-1 beta IL-6, and IL-8 mRNAs were significantly elevated in animals ventilated with 0 PEEP compared with 4 PEEP. The percentage fractional area of collapsed alveoli was significantly higher for 0 PEEP compared with 4 and 7 PEEP groups. Mechanical ventilation increased the expression of proinflammatory mediators in surfactant-treated preterm lungs and the use of 4 PEEP minimized this response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:00:08