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Titolo:
Clinical importance of Alternaria exposure in children
Autore:
Downs, SH; Mitakakis, TZ; Marks, GB; Car, NG; Belousova, EG; Leuppi, JD; Xuan, W; Downie, SR; Tobias, A; Peat, JK;
Indirizzi:
Univ Sydney, Inst Resp Med, Sydney, NSW, Australia Univ Sydney Sydney NSWAustralia , Inst Resp Med, Sydney, NSW, Australia Univ Sydney, Sch Biol Sci, Sydney, NSW, Australia Univ Sydney Sydney NSW Australia y, Sch Biol Sci, Sydney, NSW, Australia Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW, Australia Charles Sturt Univ Wagga Wagga NSW Australia Wagga Wagga, NSW, Australia New Childrens Hosp, Clin Epidemiol Unit, Westmead, NSW, Australia New Childrens Hosp Westmead NSW Australia Unit, Westmead, NSW, Australia Hosp Santa Cruz & San Pablo, Dept Clin Epidemiol & Publ Hlth, Barcelona, Spain Hosp Santa Cruz & San Pablo Barcelona Spain Publ Hlth, Barcelona, Spain
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 164, anno: 2001,
pagine: 455 - 459
SICI:
1073-449X(20010801)164:3<455:CIOAEI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; ALLERGIC SENSITIZATION; LONGITUDINAL DATA; CHILDHOOD ASTHMA; CLIMATIC REGIONS; ALT-I; POPULATION; SEVERITY; OUTDOOR; SPORE;
Keywords:
Alternaria; airway responsiveness; asthma; fungi; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Downs, SH Inst Resp Med, POB M77,Missenden Rd Post Off, Camperdown, NSW 2050, Australia Inst Resp Med POB M77,Missenden Rd Post Off Camperdown NSW Australia 2050
Citazione:
S.H. Downs et al., "Clinical importance of Alternaria exposure in children", AM J R CRIT, 164(3), 2001, pp. 455-459

Abstract

The fungus Alternaria is known to be allergenic and is one of the most common fungi worldwide. We investigated the extent to which exposure to Alternaria increases the severity of asthma. We undertook a prospective cohort study in Australia of 399 school children who had positive skin tests to one or more aeroallergens. Airway responsiveness to histamine, wheeze, and bronchodilator use in 1 mo was measured five times between 1997 and 1999. Airway hyperresponsiveness was defined as PD20FEV1 = 3.9 mu mol histamine. Airborne concentrations of Alternaria spores were measured throughout the study,and mean daily concentrations over 1 mo ranged from 2.2 to 307.7 spores/m(3) of ambient air. Using generalized estimating equations, we found that airway responsiveness, wheeze, and bronchodilator use increased significantlyin association with increased spore concentrations and that the increase in airway responsiveness was greater in children sensitized to Alternarxia than in other children (p = 0.01). The odds ratio for airway hyperresponsiveness in children sensitized to Alternaria was 1.26 (95% CI, 1.14 to 1.39) after an increase in mean exposure of 100 spore/m(3)/d over 1 mo. These results suggest that Alternaria allergens contribute to severe asthma in regions where exposure to the fungus is high.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 08:11:16