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Titolo:
Exercise inhibits epithelial sodium channels in patients with cystic fibrosis
Autore:
Hebestreit, A; Kersting, U; Basler, B; Jeschke, R; Hebestreit, H;
Indirizzi:
Univ Wurzburg, Kinderklin, Mukoviszidoseambulanz, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 bulanz, D-97080 Wurzburg, Germany Univ Wurzburg, Inst Klin Biochem & Pathobiochem, D-97080 Wurzburg, GermanyUniv Wurzburg Wurzburg Germany D-97080 iochem, D-97080 Wurzburg, Germany
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 164, anno: 2001,
pagine: 443 - 446
SICI:
1073-449X(20010801)164:3<443:EIESCI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOLAMINE THRESHOLDS; PULMONARY-FUNCTION; NASAL EPITHELIUM; AIRWAY EPITHELIA; NITRIC-OXIDE; TRANSPORT; CHILDREN; LACTATE; FITNESS; PROGRAM;
Keywords:
CF; nasal potential difference; cycle ergometry; CFTR; amiloride sensitive sodium channel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hebestreit, A Univ Wurzburg, Kinderklin, Mukoviszidoseambulanz, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080
Citazione:
A. Hebestreit et al., "Exercise inhibits epithelial sodium channels in patients with cystic fibrosis", AM J R CRIT, 164(3), 2001, pp. 443-446

Abstract

The aim of this study was to determine the effects of a single exercise bout on luminal Cl- and Na+ conductance in the respiratory epithelium of patients with cystic fibrosis (CF). In nine patients with CF and nine healthy control subjects, the transepithelial electrical potential difference (PID) of the nasal respiratory epithelium was recorded, first at rest and then during moderate-intensity exercise. Under both conditions, PD was first measured while superfusing the epithelium with isotonic saline. Then, the effects of amilorlde and amiloride plus low chloride plus isoproterenol were determined. Exercise resulted in a significant lower PID compared with rest in patients with CF (-6.6 +/- 16.6 mV versus -33.6 +/- 10.0 mV, p < 0.0001) and control subjects (0.1 +/- 8.7 mV versus -7.1 +/- 5.1 mV, p < 0.01). The effects of amilorlde on PID were reduced during exercise compared with rest in patients with CF (+15.8 +/- 9.5 mV versus + 26.1 +/- 11.0 mV, p < 0.01) and control subjects (+5.8 +/- 4.8 mV versus +10.0 +/- 3.1 mV, p < 0.01). There was no effect of exercise on chloride conductance in patients with CF and control subjects. We conclude that moderate-intensity exercise partially blocks the amiloride-sensitive sodium conductance in the respiratory epithelium. The inhibition of luminal sodium conductance could increase water content of the mucus in the CF lung during exercise and may, in part, explain the beneficial effects of exercise in patients with CF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 08:49:01